Sugi Predict

Sugi Predict / Compounds / SCHEMBL3420052

SCHEMBL3420052

SCHEMBL3420052

O=C(O)CC(=O)OC(=O)NCc1ccccc1

nearest known ligand 0.55

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ GAA P10253 1/20 0.49
▸ BCHE P06276 2/20 0.48
▸ ALDH1A1 P00352 2/20 0.47
▸ KMT2A Q03164 3/20 0.47
▸ HPGD P15428 2/20 0.47
▸ MEN1 O00255 1/20 0.47
▸ CYP1A2 P05177 1/20 0.47
▸ CYP2D6 P10635 1/20 0.47
▸ CYP2C9 P11712 1/20 0.47
▸ TSHR P16473 1/20 0.47
▸ CYP2C19 P33261 1/20 0.47
▸ PPID Q08752 1/20 0.46
▸ EPHX1 P07099 1/20 0.46
▸ LMNA P02545 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9383944 0.84 CYP1A2 (0.54) GAABCHEALDH1A1KMT2AHPGD
SCHEMBL299978 0.81 CYP2D6 (0.51) GAABCHEALDH1A1KMT2AHPGD
SCHEMBL6226310 0.80 CYP1A2 (0.53) GAABCHEALDH1A1KMT2AHPGD
SCHEMBL28020779 0.79 CYP1A2 (0.51) GAABCHEALDH1A1KMT2AHPGD
SCHEMBL3072294 0.79 NCEH1 (0.49) GAABCHEALDH1A1KMT2AHPGD
SCHEMBL3070065 0.79 ALDH1A1 (0.55) GAABCHEALDH1A1KMT2AHPGD
SCHEMBL3075342 0.77 PLAU (0.50) GAABCHEALDH1A1KMT2AHPGD
SCHEMBL22281955 0.77 ALDH1A1 (0.50) GAABCHEALDH1A1KMT2AHPGD
SCHEMBL8621389 0.77 GAA (0.55) GAABCHEALDH1A1KMT2AHPGD
SCHEMBL1720194 0.77 ALDH1A1 (0.67) GAABCHEALDH1A1KMT2AHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230227414-A1 Prolyl Hydroxylase Inhibitors GLAXOSMITHKLINE LLC (US) 2023-07-20 — — US disclosed
US-11643397-B2 Prolyl hydroxylase inhibitors GLAXOSMITHKLINE LLC (US) 2023-05-09 — — US disclosed
US-20210347740-A1 Prolyl Hydroxylase Inhibitors GLAXOSMITHKLINE LLC (US) 2021-11-11 — — US disclosed
US-20200157055-A1 Prolyl Hydroxylase Inhibitors GLAXOSMITHKLINE LLC (US) 2020-05-21 — — US disclosed
US-10336711-B2 Prolyl hydroxylase inhibitors GLAXOSMITHKLINE LLC (US) 2019-07-02 — — US disclosed
US-20180305323-A1 Prolyl Hydroxylase Inhibitors GLAXOSMITHKLINE LLC (US) 2018-10-25 — — US disclosed
US-10035779-B2 Prolyl hydroxylase inhibitors GlaxoSmithKline, LLC (US) 2018-07-31 — — US disclosed
EP-2037922-B9 PROLYL HYDROXYLASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2017-08-23 — — EP disclosed
US-20160297772-A1 PROLYL HYDROXYLASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2016-10-13 — — US disclosed
US-20150315157-A1 PROLYL HYDROXYLASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2015-11-05 — — US disclosed
US-20140336383-A1 PROLYL HYDROXYLASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2014-11-13 — — US disclosed
US-8815884-B2 Prolyl hydroxylase inhibitors GLAXOSMITHKLINE LLC (US) 2014-08-26 — — US disclosed
US-20140024666-A1 PROLYL HYDROXYLASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2014-01-23 — — US disclosed
EP-2037922-B1 PROLYL HYDROXYLASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2014-01-22 — — EP disclosed
US-8557834-B2 Prolyl hydroxylase inhibitors GLAXOSMITHKLINE LLC (US) 2013-10-15 — — US disclosed
US-20130072487-A1 PROLYL HYDROXYLASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2013-03-21 — — US disclosed
US-8324208-B2 Prolyl hydroxylase inhibitors GLAXOSMITHKLINE LLC (US) 2012-12-04 — — US disclosed
US-20100113444-A1 PROLYL HYDROXYLASE INHIBITORS SMITHKLINE BEECHAM CORPORATION 2010-05-06 — — US disclosed
EP-2037922-A2 PROLYL HYDROXYLASE INHIBITORS SmithKline Beecham Corporation (US) 2009-03-25 — — EP disclosed
WO-2007150011-A2 PROLYL HYDROXYLASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2007-12-27 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140024666-A1 PROLYL HYDROXYLASE INHIBITORS HIF1AN, EGLN3, EGLN2 GAA 224/4885BCHE 4285/4885ALDH1A1 242/4885
US-11643397-B2 Prolyl hydroxylase inhibitors HIF1AN, EGLN3, EGLN2 GAA 224/4885BCHE 4285/4885ALDH1A1 242/4885
US-20210347740-A1 Prolyl Hydroxylase Inhibitors HIF1AN, EGLN3, EGLN2 GAA 224/4885BCHE 4285/4885ALDH1A1 242/4885
US-20130072487-A1 PROLYL HYDROXYLASE INHIBITORS HIF1AN, EGLN3, EGLN2 GAA 224/4885BCHE 4285/4885ALDH1A1 242/4885
US-20100113444-A1 PROLYL HYDROXYLASE INHIBITORS HIF1AN, EGLN3, EGLN2 GAA 170/4885BCHE 4202/4885ALDH1A1 217/4885
US-10336711-B2 Prolyl hydroxylase inhibitors HIF1AN, EGLN3, EGLN2 GAA 224/4885BCHE 4285/4885ALDH1A1 242/4885
US-20140336383-A1 PROLYL HYDROXYLASE INHIBITORS HIF1AN, EGLN3, EGLN2 GAA 224/4885BCHE 4285/4885ALDH1A1 242/4885
US-20160297772-A1 PROLYL HYDROXYLASE INHIBITORS HIF1AN, EGLN3, EGLN2 GAA 224/4885BCHE 4285/4885ALDH1A1 242/4885
US-20200157055-A1 Prolyl Hydroxylase Inhibitors HIF1AN, EGLN3, EGLN2 GAA 224/4885BCHE 4285/4885ALDH1A1 242/4885
US-20180305323-A1 Prolyl Hydroxylase Inhibitors HIF1AN, EGLN3, EGLN2 GAA 224/4885BCHE 4285/4885ALDH1A1 242/4885
US-10035779-B2 Prolyl hydroxylase inhibitors HIF1AN, EGLN3, EGLN2 GAA 224/4885BCHE 4285/4885ALDH1A1 242/4885
US-20230227414-A1 Prolyl Hydroxylase Inhibitors HIF1AN, EGLN3, EGLN2 GAA 224/4885BCHE 4285/4885ALDH1A1 242/4885
US-20150315157-A1 PROLYL HYDROXYLASE INHIBITORS HIF1AN, EGLN3, EGLN2 GAA 224/4885BCHE 4285/4885ALDH1A1 242/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.