Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2999891 | 1.00 | ALDH1A1 (0.41) | ALDH1A1NPC1TDP1SMN1; SMN2HPGD | |
| SCHEMBL13247959 | 1.00 | ALDH1A1 (0.41) | ALDH1A1NPC1TDP1SMN1; SMN2HPGD | |
| SCHEMBL13247957 | 0.88 | ALDH1A1 (0.40) | ALDH1A1NPC1TDP1SMN1; SMN2HPGD | |
| SCHEMBL3223816 | 0.88 | ALDH1A1 (0.40) | ALDH1A1NPC1TDP1SMN1; SMN2HPGD | |
| SCHEMBL2493672 | 0.85 | PDE4A (0.46) | NPC1KMT2AMAPK14 | |
| SCHEMBL13345937 | 0.85 | ALDH1A1 (0.45) | ALDH1A1NPC1TDP1SMN1; SMN2HPGD | |
| SCHEMBL13247973 | 0.85 | MAPK14 (0.38) | NPC1SMN1; SMN2KMT2ATSHRMAPK14 | |
| SCHEMBL13267945 | 0.85 | MAPK14 (0.39) | NPC1KMT2AMAPK14 | |
| SCHEMBL13247944 | 0.84 | ALDH1A1 (0.44) | ALDH1A1TDP1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL2244234 | 0.84 | DGAT1 (0.48) | ALDH1A1NPC1TDP1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100184813-A1 | CHEMICAL COMPOUNDS 553 | ASTRAZENECA AB (SE) | 2010-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100184813-A1 | CHEMICAL COMPOUNDS 553 | GCGR, DGAT1, GPBAR1 | ALDH1A1 559/4885NPC1 170/4885TDP1 3435/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.