Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | CTSD | P07339 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28959472 | 1.00 | LMNA (0.38) | LMNARAB9AKMT2ANPC1CTSD | |
| SCHEMBL30002409 | 0.91 | LMNA (0.38) | LMNARAB9AKMT2ANPC1ALDH1A1 | |
| SCHEMBL28892558 | 0.91 | LMNA (0.38) | LMNARAB9AKMT2ANPC1ALDH1A1 | |
| SCHEMBL30002747 | 0.85 | LMNA (0.34) | LMNARAB9AKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL30002604 | 0.83 | NPC1 (0.34) | LMNARAB9ANPC1SMN1; SMN2GAA | |
| SCHEMBL28892360 | 0.83 | NPC1 (0.34) | LMNARAB9ANPC1SMN1; SMN2GAA | |
| SCHEMBL30002751 | 0.82 | LMNA (0.35) | LMNARAB9AKMT2ANPC1ALDH1A1 | |
| SCHEMBL30002621 | 0.82 | GAA (0.40) | LMNARAB9AKMT2ANPC1ALDH1A1 | |
| SCHEMBL28892761 | 0.82 | GAA (0.40) | LMNARAB9AKMT2ANPC1ALDH1A1 | |
| SCHEMBL30003319 | 0.80 | GAA (0.40) | LMNARAB9AKMT2ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115232144-B | Nitrogen-containing condensed ring derivative, pharmaceutical composition, and preparation method and application thereof | 长春金赛药业有限责任公司 | 2024-04-02 | — | — | CN | disclosed |
| CN-115232144-A | Nitrogen-containing fused ring derivative, pharmaceutical composition, preparation method and application thereof | 长春金赛药业有限责任公司 | 2022-10-25 | — | — | CN | disclosed |