SCHEMBL30002435

SCHEMBL30002435

COc1cc(F)c(N)cc1S(=O)(=O)n1ccc2c(F)cccc21

nearest known ligand 0.53

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 13/20 0.53
FABP4 P15090 5/20 0.50
POLB P06746 1/20 0.40
PKM P14618 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30002530 0.90 HTR6 (0.48) HTR6FABP4POLB
SCHEMBL28892124 0.85 HTR6 (0.47) HTR6FABP4POLBPKM
SCHEMBL28892904 0.81 HTR6 (0.52) HTR6FABP4POLBPKM
SCHEMBL30003158 0.81 HTR6 (0.51) HTR6FABP4POLBPKM
SCHEMBL30002434 0.80 HTR6 (0.49) HTR6FABP4POLB
SCHEMBL28959478 0.80 HTR6 (0.49) HTR6FABP4POLB
SCHEMBL28892452 0.79 HTR6 (0.51) HTR6FABP4POLBPKM
SCHEMBL30002457 0.79 HTR6 (0.51) HTR6FABP4POLBPKM
SCHEMBL30002912 0.77 HTR6 (0.49) HTR6FABP4POLB
SCHEMBL30002820 0.77 HTR6 (0.49) HTR6FABP4POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115232144-B Nitrogen-containing condensed ring derivative, pharmaceutical composition, and preparation method and application thereof 长春金赛药业有限责任公司 2024-04-02 CN disclosed
CN-115232144-A Nitrogen-containing fused ring derivative, pharmaceutical composition, preparation method and application thereof 长春金赛药业有限责任公司 2022-10-25 CN disclosed