Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 16/20 | 0.69 |
| ▸ | CASP7 | P55210 | 12/20 | 0.69 |
| ▸ | CASP1 | P29466 | 9/20 | 0.69 |
| ▸ | CASP9 | P55211 | 6/20 | 0.69 |
| ▸ | CASP10 | Q92851 | 3/20 | 0.55 |
| ▸ | CASP4 | P49662 | 3/20 | 0.54 |
| ▸ | CASP8 | Q14790 | 3/20 | 0.53 |
| ▸ | CASP5 | P51878 | 1/20 | 0.53 |
| ▸ | CASP6 | P55212 | 1/20 | 0.53 |
| ▸ | CTSB | P07858 | 1/20 | 0.51 |
| ▸ | CTSK | P43235 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2039051 | 0.91 | CASP3 (0.69) | CASP3CASP7CASP1CASP9CASP10 | |
| SCHEMBL29362585 | 0.90 | CASP3 (0.76) | CASP3CASP7CASP1CASP9CASP10 | |
| SCHEMBL17326941 | 0.89 | CASP3 (0.72) | CASP3CASP7CASP1CASP9CASP10 | |
| SCHEMBL29732392 | 0.89 | CASP3 (0.71) | CASP3CASP7CASP1CASP9CASP10 | |
| SCHEMBL20239336 | 0.89 | CASP3 (0.71) | CASP3CASP7CASP1CASP9CASP10 | |
| SCHEMBL29818103 | 0.87 | CASP3 (0.64) | CASP3CASP7CASP1CASP9CASP4 | |
| Naphthalene SCHEMBL8414904 | 0.87 | CASP1 (0.64) | CASP3CASP7CASP1CASP9CASP4 | |
| SCHEMBL7420154 | 0.87 | CASP1 (0.64) | CASP3CASP7CASP1CASP9CASP10 | |
| SCHEMBL16770334 | 0.86 | CASP3 (0.68) | CASP3CASP7CASP1CASP9CASP10 | |
| SCHEMBL2744395 | 0.86 | CASP3 (0.68) | CASP3CASP7CASP1CASP9CASP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024124212-A1 | DEVICES AND METHODS FOR DETECTION OF DISEASE BIOMARKERS AND THERAPEUTIC EFFECTIVENESS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2024-06-13 | — | — | WO | claimed |
| US-20240115649-A1 | CASPASE INHIBITION TO ENHANCE REGENERATION AND REPAIR AFTER SKIN OR GUT INJURY AND TO TREAT BACTERIAL OR VIRAL INFECTIONS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2024-04-11 | — | — | US | claimed |
| WO-2024124212-A1 | DEVICES AND METHODS FOR DETECTION OF DISEASE BIOMARKERS AND THERAPEUTIC EFFECTIVENESS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2024-06-13 | — | — | WO | disclosed |
| US-20240115649-A1 | CASPASE INHIBITION TO ENHANCE REGENERATION AND REPAIR AFTER SKIN OR GUT INJURY AND TO TREAT BACTERIAL OR VIRAL INFECTIONS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2024-04-11 | — | — | US | disclosed |
| US-20230218705-A1 | CASPASE INHIBITORS TO ENHANCE INJURY REPAIR AND TO TREAT BACTERIAL AND VIRAL INFECTIONS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-07-13 | — | — | US | disclosed |
| US-20230056661-A1 | METHODS AND COMPOSITIONS FOR PRODUCTION OF XENOGENEIC ISLET CELLS AND TREATMENT OF INSULIN-RESISTANT OR -DEFICIENT CONDITIONS WITH THE SAME | JPMORGAN CHASE BANK, N.A. | 2023-02-23 | — | — | US | disclosed |
| EP-4126010-A1 | CASPASE INHIBITORS TO ENHANCE INJURY REPAIR AND TO TREAT BACTERIAL AND VIRAL INFECTIONS | The Johns Hopkins University (US) | 2023-02-08 | — | — | EP | disclosed |
| CN-115605585-A | Methods and compositions for producing xenogenic islet cells and treating insulin resistance or deficiency disorders with said xenogenic islet cells | 杭州启函生物科技有限公司（CN） | 2023-01-13 | — | — | CN | disclosed |
| CN-115551536-A | Caspase inhibitors for enhanced wound repair and treatment of bacterial and viral infections | 约翰斯·霍普金斯大学 | 2022-12-30 | — | — | CN | disclosed |
| EP-4087917-A1 | METHODS AND COMPOSITIONS FOR PRODUCTION OF XENOGENEIC ISLET CELLS AND TREATMENT OF INSULIN-RESISTANT OR -DEFICIENT CONDITIONS WITH THE SAME | Hangzhou Qihan Biotechnology Co., Ltd. (CN) | 2022-11-16 | — | — | EP | disclosed |