Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.80 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | HTR6 | P50406 | 2/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | CPT1A | P50416 | 4/20 | 0.46 |
| ▸ | CPT2 | P23786 | 3/20 | 0.44 |
| ▸ | CPT1B | Q92523 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30002743 | 0.81 | POLB (0.53) | POLBMEN1KMT2AMAPTHTR6 | |
| SCHEMBL3108169 | 0.79 | CRHBP (0.66) | POLBMEN1KMT2AMAPTCRHBP | |
| SCHEMBL28892515 | 0.74 | POLB (0.52) | POLBKMT2AMAPTTSHRALDH1A1 | |
| SCHEMBL30002695 | 0.74 | POLB (0.52) | POLBKMT2AMAPTTSHRALDH1A1 | |
| SCHEMBL14758405 | 0.71 | NPC1 (1.00) | POLBMEN1KMT2AMAPTNPC1 | |
| SCHEMBL9053909 | 0.70 | NPC1 (0.64) | POLBMEN1KMT2AMAPTNPC1 | |
| SCHEMBL34475669 | 0.69 | CYP2C9 (0.66) | POLBMEN1KMT2AMAPTNPC1 | |
| SCHEMBL25754848 | 0.69 | NPC1 (0.62) | POLBMEN1KMT2ANPC1HTR6 | |
| SCHEMBL5474787 | 0.68 | NPC1 (0.58) | POLBMEN1KMT2ANPC1HTR6 | |
| SCHEMBL7343643 | 0.68 | NPC1 (0.59) | POLBMEN1KMT2AMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115232144-B | Nitrogen-containing condensed ring derivative, pharmaceutical composition, and preparation method and application thereof | 长春金赛药业有限责任公司 | 2024-04-02 | — | — | CN | disclosed |
| CN-115232144-A | Nitrogen-containing fused ring derivative, pharmaceutical composition, preparation method and application thereof | 长春金赛药业有限责任公司 | 2022-10-25 | — | — | CN | disclosed |