Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | APEX1 | P27695 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | PDE4A | P27815 | 1/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CPT1A | P50416 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CPT2 | P23786 | 2/20 | 0.47 |
| ▸ | CPT1B | Q92523 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9048387 | 0.81 | PDE4A (0.74) | MAPTMEN1KMT2APDE4APDE4B | |
| SCHEMBL14758405 | 0.78 | NPC1 (1.00) | NPC1POLBMAPTMEN1KMT2A | |
| SCHEMBL9053972 | 0.78 | NPC1 (0.59) | NPC1POLBMAPTMEN1KMT2A | |
| SCHEMBL16217090 | 0.76 | NPC1 (0.74) | NPC1POLBMAPTMEN1KMT2A | |
| SCHEMBL8540322 | 0.75 | POLB (0.73) | POLBAPEX1MAPTMEN1KMT2A | |
| SCHEMBL3000456 | 0.73 | NPC1 (0.59) | NPC1POLBMAPTMEN1KMT2A | |
| SCHEMBL31750670 | 0.73 | NPC1 (0.62) | NPC1POLBMAPTMEN1KMT2A | |
| SCHEMBL8544209 | 0.73 | APEX1 (0.75) | POLBAPEX1ALDH1A1TSHRLMNA | |
| SCHEMBL8541971 | 0.73 | APEX1 (0.75) | POLBAPEX1ALDH1A1TSHRLMNA | |
| SCHEMBL2995685 | 0.73 | NPC1 (0.58) | NPC1POLBMEN1KMT2ACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0734378-A1 | AMINOSULPHONYL-PHENYL-1H-PYRROLE DERIVATIVES, METHOD OF THEIR PREPARATION AND THEIR USE | SMITHKLINE BEECHAM PLC (GB) | 1996-10-02 | — | — | EP | disclosed |
| WO-1995016674-A1 | AMINOSULPHONYL-PHENYL-1H-PYRROLE DERIVATIVES, METHOD OF THEIR PREPARATION AND THEIR USE | SMITHKLINE BEECHAM PLC (GB) | 1995-06-22 | — | — | WO | disclosed |