Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6050734 | 0.82 | PTGS2 (0.58) | PTGS2 | |
| SCHEMBL6050878 | 0.76 | PTGS2 (0.72) | PTGS2 | |
| SCHEMBL5502727 | 0.75 | PTGS2 (1.00) | PTGS2 | |
| SCHEMBL6314880 | 0.74 | PTGS2 (0.45) | PTGS2 | |
| SCHEMBL8645506 | 0.74 | PTGS2 (0.75) | PTGS2 | |
| SCHEMBL5708943 | 0.73 | PTGS2 (0.58) | PTGS2 | |
| Hydrogen Sulfide SCHEMBL27744400 | 0.73 | PTGS2 (0.96) | PTGS2 | |
| SCHEMBL6309243 | 0.73 | PTGS2 (0.44) | PTGS2 | |
| SCHEMBL8770202 | 0.73 | PTGS2 (0.79) | PTGS2 | |
| SCHEMBL1687503 | 0.73 | PTGS2 (0.79) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220409568-A1 | PURIFIED FORMS OF ROFECOXIB, METHODS OF MANUFACTURE AND USE | Tremeau Pharmaceuticals, Inc. (US) | 2022-12-29 | — | — | US | disclosed |
| US-20220362206-A1 | PURIFIED FORMS OF ROFECOXIB, METHODS OF MANUFACTURE AND USE | Tremeau Pharmaceuticals, Inc. (US) | 2022-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220362206-A1 | PURIFIED FORMS OF ROFECOXIB, METHODS OF MANUFACTURE AND USE | ITGA2B, F13B, F11 | PTGS2 764/4885 |
| US-20220409568-A1 | PURIFIED FORMS OF ROFECOXIB, METHODS OF MANUFACTURE AND USE | ITGA2B, F13B, F11 | PTGS2 764/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.