Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.53 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.53 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7920173 | 1.00 | PARP10 (0.53) | PARP10PARP11PIM1CSNK1A1CDK5 | |
| SCHEMBL1661783 | 0.96 | PARP10 (0.53) | PARP10PARP11PIM1CSNK1A1CDK5 | |
| SCHEMBL29514736 | 0.96 | PARP10 (0.53) | PARP10PARP11PIM1CSNK1A1CDK5 | |
| SCHEMBL28004728 | 0.89 | PARP10 (0.47) | PARP10PARP11PIM1CSNK1A1CDK5 | |
| SCHEMBL29429928 | 0.88 | PARP10 (0.56) | PARP10PARP11PIM1CSNK1A1CDK5 | |
| SCHEMBL163925 | 0.88 | PARP10 (0.56) | PARP10PARP11PIM1CSNK1A1CDK5 | |
| Methylamine SCHEMBL27811293 | 0.82 | PARP10 (0.51) | PARP10PARP11PIM1CSNK1A1CDK5 | |
| SCHEMBL28041457 | 0.79 | MAOA (0.56) | KDM4EHSD17B10CYP2A6MAOAMAOB | |
| SCHEMBL5752790 | 0.78 | PARP1 (0.55) | PARP10PARP11KDM4ECYP2A6MAOA | |
| SCHEMBL7052870 | 0.77 | PARP10 (0.58) | PARP10PARP11PIM1CSNK1A1CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022218311-A1 | MODULATORS OF BCL-2 OR BCL-2/BCL-XL AND USES THEREOF | APPICINE THERAPEUTICS (HK) LIMITED (CN) | 2022-10-20 | — | — | WO | disclosed |