Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.53 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.53 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30003712 | 1.00 | PARP10 (0.53) | PARP10PARP11PIM1CSNK1A1CDK5 | |
| SCHEMBL1661783 | 0.96 | PARP10 (0.53) | PARP10PARP11PIM1CSNK1A1CDK5 | |
| SCHEMBL29514736 | 0.96 | PARP10 (0.53) | PARP10PARP11PIM1CSNK1A1CDK5 | |
| SCHEMBL28004728 | 0.89 | PARP10 (0.47) | PARP10PARP11PIM1CSNK1A1CDK5 | |
| SCHEMBL29429928 | 0.88 | PARP10 (0.56) | PARP10PARP11PIM1CSNK1A1CDK5 | |
| SCHEMBL163925 | 0.88 | PARP10 (0.56) | PARP10PARP11PIM1CSNK1A1CDK5 | |
| Methylamine SCHEMBL27811293 | 0.82 | PARP10 (0.51) | PARP10PARP11PIM1CSNK1A1CDK5 | |
| SCHEMBL28041457 | 0.79 | MAOA (0.56) | KDM4EHSD17B10CYP2A6MAOAMAOB | |
| SCHEMBL5752790 | 0.78 | PARP1 (0.55) | PARP10PARP11KDM4ECYP2A6MAOA | |
| SCHEMBL7052870 | 0.77 | PARP10 (0.58) | PARP10PARP11PIM1CSNK1A1CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3746064-B1 | COMPOUNDS FOR USE IN THE TREATMENT OF ACUTE BRAIN INJURY | UNIV COPENHAGEN (DK) | 2025-04-16 | — | — | EP | disclosed |
| US-20240391865-A1 | COMPOUNDS FOR THE TREATMENT OF ACUTE BRAIN INJURY | OTAGO INNOVATION LIMITED (NZ) | 2024-11-28 | — | — | US | disclosed |
| US-12077495-B2 | Compounds for the treatment of acute brain injury | Københavns Universitet (DK) | 2024-09-03 | — | — | US | disclosed |
| US-20240239792-A1 | MODULATORS OF BCL-2 OR BCL-2/BCL-XL AND USES THEREOF | ASIA VISION LIMITED (CN) | 2024-07-18 | — | — | US | disclosed |
| US-20240239792-A1 | MODULATORS OF BCL-2 OR BCL-2/BCL-XL AND USES THEREOF | ASIA VISION LIMITED (CN) | 2024-07-18 | — | — | US | disclosed |
| US-20240239792-A1 | MODULATORS OF BCL-2 OR BCL-2/BCL-XL AND USES THEREOF | ASIA VISION LIMITED (CN) | 2024-07-18 | — | — | US | disclosed |
| US-20210122700-A1 | COMPOUNDS FOR THE TREATMENT OF ACUTE BRAIN INJURY | UNIVERSITY OF OTAGO (NZ) | 2021-04-29 | — | — | US | disclosed |
| EP-3746064-A1 | COMPOUNDS FOR THE TREATMENT OF ACUTE BRAIN INJURY | Københavns Universitet (DK) | 2020-12-09 | — | — | EP | disclosed |
| EP-2704571-B1 | AMINO-PYRIDINE-CONTAINING SPLEEN TYROSINE KINASE (SYK) INHIBITORS | MERCK SHARP & DOHME (US) | 2020-04-22 | — | — | EP | disclosed |
| EP-2704571-B1 | AMINO-PYRIDINE-CONTAINING SPLEEN TYROSINE KINASE (SYK) INHIBITORS | MERCK SHARP & DOHME (US) | 2020-04-22 | — | — | EP | disclosed |
| WO-2012151137-A1 | AMINO-PYRIDINE-CONTAINING SPLEEN TYROSINE KINASE (SYK) INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-11-08 | — | — | WO | disclosed |
| WO-2012151137-A1 | AMINO-PYRIDINE-CONTAINING SPLEEN TYROSINE KINASE (SYK) INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-11-08 | — | — | WO | disclosed |
| US-20110251207-A1 | BIARYL-SPIROAMINOOXAZOLINE ANALOGUES AS ALPHA 2C ADRENERGIC RECEPTOR MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2011-10-13 | — | — | US | disclosed |
| US-20110251207-A1 | BIARYL-SPIROAMINOOXAZOLINE ANALOGUES AS ALPHA 2C ADRENERGIC RECEPTOR MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2011-10-13 | — | — | US | disclosed |
| WO-2010042473-A1 | BIARYL SPIROAMINOOXAZOLINE ANALOGUES AS ALPHA2C ADRENERGIC RECEPTOR MODULATORS | SCHERING CORPORATION (US) | 2010-04-15 | — | — | WO | disclosed |
| WO-2010042475-A1 | SPIROAMINOOXAZOLINE ANALOGUES AS ALPHA2C ADRENERGIC RECEPTOR MODULATORS | SCHERING CORPORATION (US) | 2010-04-15 | — | — | WO | disclosed |
| CN-1110485-C | 1-arylsulphonyl, aryl(thio) carbonyl pyridazino derivatives and methods of preparation | ORTHO PHARMA CORP (US) | 2003-06-04 | — | — | CN | disclosed |
| CN-1207091-A | 1-arylsulphonyl, aryl(thio) carbonyl pyridazino derivatives and methods of preparation | ORTHO PHARMA CORP (US) | 1999-02-03 | — | — | CN | disclosed |
| US-5753655-A | PROGESTINS OR ANTIPROGESTINS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1998-05-19 | — | — | US | disclosed |
| WO-1997017332-A1 | 1-ARYLSULPHONYL, ARYL(THIO)CARBONYL PYRIDAZINO DERIVATIVES AND METHODS OF PREPARATION | ORTHO PHARMACEUTICAL CORPORATION (US) | 1997-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12077495-B2 | Compounds for the treatment of acute brain injury | F2R, F2RL3, ARG2 | PARP10 593/4885PARP11 271/4885PIM1 3937/4885 |
| US-20240239792-A1 | MODULATORS OF BCL-2 OR BCL-2/BCL-XL AND USES THEREOF | BCL2, BCL2L2, BCL2L1 | PARP10 1868/4885PARP11 1597/4885PIM1 2995/4885 |
| US-20210122700-A1 | COMPOUNDS FOR THE TREATMENT OF ACUTE BRAIN INJURY | F2R, F2RL3, ARG2 | PARP10 702/4885PARP11 294/4885PIM1 3978/4885 |
| US-20240391865-A1 | COMPOUNDS FOR THE TREATMENT OF ACUTE BRAIN INJURY | F2R, F2RL3, ARG2 | PARP10 702/4885PARP11 294/4885PIM1 3978/4885 |
| US-20110251207-A1 | BIARYL-SPIROAMINOOXAZOLINE ANALOGUES AS ALPHA 2C ADRENERGIC RECEPTOR MODULATORS | ADRA2C, ADRB2, ADRB3 | PARP10 3326/4885PARP11 3038/4885PIM1 4850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.