Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NPY1R | P25929 | 1/20 | 0.41 |
| ▸ | NPY2R | P49146 | 1/20 | 0.41 |
| ▸ | CTSV | O60911 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3945043 | 1.00 | KMT2A (0.56) | KMT2AHTTMEN1LMNAALDH1A1 | |
| SCHEMBL623566 | 0.87 | ALDH1A1 (0.54) | KMT2AHTTMEN1LMNAALDH1A1 | |
| SCHEMBL89086 | 0.82 | ALDH1A1 (0.50) | KMT2AHTTMEN1ALDH1A1MAPT | |
| SCHEMBL30406917 | 0.82 | ALDH1A1 (0.50) | KMT2AHTTMEN1ALDH1A1MAPT | |
| SCHEMBL3945186 | 0.82 | MEN1 (0.51) | KMT2AHTTMEN1LMNAALDH1A1 | |
| SCHEMBL8528596 | 0.81 | HTT (0.68) | KMT2AHTTMEN1LMNAALDH1A1 | |
| SCHEMBL394667 | 0.81 | TSHR (0.57) | KMT2AHTTMEN1LMNAALDH1A1 | |
| SCHEMBL29739625 | 0.81 | CA1 (0.53) | KMT2AHTTMEN1LMNAALDH1A1 | |
| SCHEMBL18497802 | 0.81 | CA1 (0.53) | KMT2AHTTMEN1LMNAALDH1A1 | |
| SCHEMBL29697071 | 0.81 | TSHR (0.57) | KMT2AHTTMEN1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4323350-A1 | ISOINDOLINONE COMPOUNDS | Monte Rosa Therapeutics AG (CH) | 2024-02-21 | — | — | EP | disclosed |
| WO-2022219407-A1 | ISOINDOLINONE COMPOUNDS | MONTE ROSA THERAPEUTICS AG (CH) | 2022-10-20 | — | — | WO | disclosed |