Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | LIPG | Q9Y5X9 | 3/20 | 0.43 |
| ▸ | LPL | P06858 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | F11 | P03951 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 5/20 | 0.38 |
| ▸ | CA2 | P00918 | 5/20 | 0.38 |
| ▸ | CA9 | Q16790 | 5/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA7 | P43166 | 2/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL516413 | 1.00 | ROCK1 (0.46) | ROCK1LIPGLPLHIF1ADGAT1 | |
| SCHEMBL24370295 | 0.89 | ROCK1 (0.38) | ROCK1LIPGLPLHIF1ADGAT1 | |
| SCHEMBL2324789 | 0.89 | LIPG (0.43) | ROCK1LIPGLPLHIF1ADGAT1 | |
| SCHEMBL28960278 | 0.89 | ROCK1 (0.46) | ROCK1LIPGLPLHIF1ADGAT1 | |
| SCHEMBL25035049 | 0.87 | HIF1A (0.43) | LIPGLPLHIF1ADGAT1F2 | |
| SCHEMBL16679092 | 0.85 | BACE1 (0.47) | ROCK1LIPGLPLHIF1ADGAT1 | |
| SCHEMBL3845797 | 0.85 | ROCK1 (0.46) | ROCK1LIPGLPLHIF1ACA1 | |
| SCHEMBL209359 | 0.84 | HIF1A (0.43) | LIPGLPLHIF1ADGAT1F2 | |
| SCHEMBL31258763 | 0.84 | CA1 (0.53) | LIPGLPLHIF1ADGAT1CA1 | |
| SCHEMBL2697552 | 0.84 | CA1 (0.53) | LIPGLPLHIF1ADGAT1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4739675-A1 | INDOLE DERIVATIVES WITH FACTOR B INHIBITORY ACTIVITY | Sitala Bio Ltd (GB) | 2026-05-13 | — | — | EP | disclosed |
| WO-2025008517-A1 | INDOLE DERIVATIVES WITH FACTOR B INHIBITORY ACTIVITY | SITALA BIO LTD (GB) | 2025-01-09 | — | — | WO | disclosed |
| US-11702409-B2 | Pyrazolyl derivatives useful as anti-cancer agents | NOVARTIS AG (CH) | 2023-07-18 | — | — | US | disclosed |
| US-20220363670-A1 | Pyrazolyl derivatives useful as anti-cancer agents | NOVARTIS AG (CH) | 2022-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11702409-B2 | Pyrazolyl derivatives useful as anti-cancer agents | PAK5, CYP51A1, SF3B5 | ROCK1 943/4885LIPG 4475/4885LPL 4281/4885 |
| US-20220363670-A1 | Pyrazolyl derivatives useful as anti-cancer agents | PAK5, CYP51A1, SF3B5 | ROCK1 943/4885LIPG 4475/4885LPL 4281/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.