SCHEMBL30004432

SCHEMBL30004432

NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(N)=O

nearest known ligand 0.53

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
FCER2 P06734 2/20 0.53
PTPN1 P18031 1/20 0.52
QRFPR Q96P65 3/20 0.51
CTSC P53634 2/20 0.49
MMP1 P03956 1/20 0.48
MME P08473 2/20 0.48
REN P00797 1/20 0.47
CTSL P07711 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29706283 0.91 MME (0.56) MME
SCHEMBL29542919 0.88 PTPN2 (0.53) PTPN1MME
SCHEMBL29773185 0.88 MME (0.59) MME
Hydrochloric Acid SCHEMBL31242481 0.87 QRFPR (0.58) FCER2PTPN1QRFPRCTSCMMP1
SCHEMBL1329813 0.86 CTSC (0.59) FCER2PTPN1QRFPRCTSCMMP1
SCHEMBL1329814 0.86 CTSC (0.59) FCER2PTPN1QRFPRCTSCMMP1
SCHEMBL30316218 0.86 PTPN1 (0.58) PTPN1
SCHEMBL8068326 0.85 MME (0.61) CTSCMME
SCHEMBL8068319 0.85 MME (0.61) CTSCMME
SCHEMBL8767006 0.83 PTPN1 (0.60) FCER2PTPN1MMP1MMECTSL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11866518-B2 Bicyclic peptide ligands specific for TSLP BICYCLETX LIMITED (GB) 2024-01-09 US disclosed
EP-4132481-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR TSLP BicycleTX Limited (GB) 2023-02-15 EP disclosed
US-20220363718-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR TSLP BICYCLETX LIMITED (GB) 2022-11-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220363718-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR TSLP TSLP, VIP, CCL2 FCER2 64/4885PTPN1 1281/4885QRFPR 341/4885
US-11866518-B2 Bicyclic peptide ligands specific for TSLP TSLP, VIP, CCL2 FCER2 64/4885PTPN1 1281/4885QRFPR 341/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.