Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.40 |
| ▸ | BACE1 | P56817 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19950199 | 1.00 | APP (0.40) | APPBACE1ALDH1A1MAPT | |
| SCHEMBL1494673 | 0.77 | ALOX15 (0.32) | APPALDH1A1MAPT | |
| SCHEMBL22081760 | 0.77 | CYP3A4 (0.48) | APPALDH1A1MAPT | |
| SCHEMBL30004351 | 0.77 | CYP3A4 (0.48) | APPALDH1A1MAPT | |
| SCHEMBL30345392 | 0.77 | ALOX15 (0.32) | APPALDH1A1MAPT | |
| SCHEMBL24803973 | 0.77 | ALDH1A1 (0.31) | APPALDH1A1MAPT | |
| SCHEMBL8999877 | 0.77 | MEN1 (0.43) | ALDH1A1MAPT | |
| SCHEMBL1100004 | 0.75 | MEN1 (0.47) | ALDH1A1MAPT | |
| SCHEMBL3157193 | 0.74 | ALOX15 (0.32) | APP | |
| SCHEMBL17203920 | 0.74 | APP (0.34) | APPBACE1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4323350-A1 | ISOINDOLINONE COMPOUNDS | Monte Rosa Therapeutics AG (CH) | 2024-02-21 | — | — | EP | disclosed |
| CN-117242060-A | Isoindolinone compounds | 蒙特罗萨医疗公司 | 2023-12-15 | — | — | CN | disclosed |
| WO-2023069731-A1 | COMPOUNDS THAT MEDIATE PROTEIN DEGRADATION AND METHODS OF USE THEREOF | MONTE ROSA THERAPEUTICS, INC. (US) | 2023-04-27 | — | — | WO | disclosed |
| CN-115819417-A | Pyrazolopyridine derivatives as HPK1 modulators and their use for the treatment of cancer | 因赛特公司 | 2023-03-21 | — | — | CN | disclosed |
| CN-109923114-B | Pyrazolopyridine derivatives as HPK1 modulators and their use for the treatment of cancer | 因赛特公司 | 2022-11-01 | — | — | CN | disclosed |
| WO-2022219407-A1 | ISOINDOLINONE COMPOUNDS | MONTE ROSA THERAPEUTICS AG (CH) | 2022-10-20 | — | — | WO | disclosed |