Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 2/20 | 0.48 |
| ▸ | JAK1 | P23458 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | F13A1 | P00488 | 1/20 | 0.46 |
| ▸ | TGM2 | P21980 | 1/20 | 0.46 |
| ▸ | TGM1 | P22735 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30005953 | 0.89 | TDP1 (0.49) | TDP1KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL30005561 | 0.85 | TDP1 (0.49) | TDP1KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL30005455 | 0.84 | TDP1 (0.52) | TDP1KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL30005465 | 0.76 | ALDH1A1 (0.73) | KMT2AMEN1NPSR1MAPTALDH1A1 | |
| SCHEMBL30005757 | 0.76 | MEN1 (0.51) | KMT2AMEN1MAPTALDH1A1HPGD | |
| SCHEMBL30005703 | 0.75 | MAPT (0.47) | TDP1KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL30006561 | 0.74 | MEN1 (0.52) | KMT2AMEN1MAPTALDH1A1PSMD14 | |
| SCHEMBL2885210 | 0.74 | NPC1 (0.81) | NPC1TDP1KMT2AMEN1PKM | |
| SCHEMBL30006437 | 0.74 | ALDH1A1 (0.68) | KMT2AMEN1NPSR1MAPTALDH1A1 | |
| SCHEMBL30005833 | 0.73 | MAPT (0.55) | KMT2AMEN1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022220725-A1 | LPXH INHIBITORS AS ANTI-INFECTIVE AGENTS | ZAMARATSKI EDOUARD (SE) | 2022-10-20 | — | — | WO | disclosed |