Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 9/20 | 0.43 |
| ▸ | KRAS | P01116 | 6/20 | 0.43 |
| ▸ | TACR1 | P25103 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | PNMT | P11086 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.35 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.35 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20327218 | 1.00 | SOS1 (0.43) | SOS1KRASTACR1TSHRMAPK1 | |
| SCHEMBL12587301 | 1.00 | SOS1 (0.43) | SOS1KRASTACR1TSHRMAPK1 | |
| Hydrochloric Acid SCHEMBL23326533 | 0.98 | SOS1 (0.42) | SOS1KRASTACR1TSHRMAPK1 | |
| Hydrochloric Acid SCHEMBL29564024 | 0.98 | SOS1 (0.42) | SOS1KRASTACR1TSHRMAPK1 | |
| Hydrochloric Acid SCHEMBL23326532 | 0.98 | SOS1 (0.42) | SOS1KRASTACR1TSHRMAPK1 | |
| Hydrochloric Acid SCHEMBL29663260 | 0.98 | SOS1 (0.42) | SOS1KRASTACR1TSHRMAPK1 | |
| SCHEMBL336049 | 0.87 | TACR1 (0.51) | TACR1PDE2APNMTIDO1TDO2 | |
| SCHEMBL7939177 | 0.87 | TACR1 (0.51) | TACR1PDE2APNMTIDO1TDO2 | |
| SCHEMBL1728680 | 0.87 | TACR1 (0.51) | TACR1PDE2APNMTIDO1TDO2 | |
| SCHEMBL6917133 | 0.87 | TACR1 (0.51) | TACR1PDE2APNMTIDO1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119039234-B | Pyridazine amide compound and preparation method and application thereof | 中国药科大学 | 2026-05-15 | — | — | CN | disclosed |
| CN-119431234-A | Benzyl amine formyl compound and preparation method and application thereof | 中国药科大学 | 2025-02-14 | — | — | CN | disclosed |
| CN-119039234-A | Pyridazine amide compound and preparation method and application thereof | 中国药科大学 | 2024-11-29 | — | — | CN | disclosed |
| EP-4322962-A1 | PHOSPHORUS DERIVATIVES AS NOVEL SOS1 INHIBITORS | Bayer Aktiengesellschaft (DE) | 2024-02-21 | — | — | EP | disclosed |
| WO-2022219035-A1 | PHOSPHORUS DERIVATIVES AS NOVEL SOS1 INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2022-10-20 | — | — | WO | disclosed |