Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 19/20 | 0.38 |
| ▸ | TPH2 | Q8IWU9 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30006142 | 0.84 | TPH1 (0.39) | TPH1TPH2 | |
| SCHEMBL24253553 | 0.79 | TPH1 (0.41) | TPH1TPH2 | |
| SCHEMBL24253760 | 0.79 | TPH1 (0.41) | TPH1TPH2 | |
| SCHEMBL24253761 | 0.79 | TPH1 (0.41) | TPH1TPH2 | |
| SCHEMBL24253877 | 0.70 | TPH1 (0.38) | TPH1TPH2 | |
| SCHEMBL30494515 | 0.70 | TPH1 (0.38) | TPH1TPH2 | |
| SCHEMBL24253749 | 0.70 | TPH1 (0.38) | TPH1TPH2 | |
| SCHEMBL30423951 | 0.70 | TPH1 (0.38) | TPH1TPH2 | |
| SCHEMBL24253844 | 0.69 | TPH1 (0.41) | TPH1TPH2 | |
| SCHEMBL24253845 | 0.69 | TPH1 (0.41) | TPH1TPH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4323062-A1 | HETEROARYL AMINOPROPANOL DERIVATIVES AS INHIBITORS OF LTA4H | Novartis AG (CH) | 2024-02-21 | — | — | EP | disclosed |
| WO-2022219546-A1 | HETEROARYL AMINOPROPANOL DERIVATIVES AS INHIBITORS OF LTA4H | NOVARTIS AG (CH) | 2022-10-20 | — | — | WO | disclosed |