Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.41 |
| ▸ | HBB | P68871 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | MLNR | O43193 | 1/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29123563 | 1.00 | MAP4K4 (0.53) | MAP4K4HRH3KCNH2JAK2JAK1 | |
| SCHEMBL3287232 | 0.82 | MAP4K4 (0.50) | MAP4K4HRH3KCNH2JAK2JAK1 | |
| SCHEMBL31473410 | 0.82 | PDE4B (0.48) | MAP4K4HRH3KCNH2JAK2JAK1 | |
| SCHEMBL3289972 | 0.82 | HRH3 (0.52) | MAP4K4HRH3KCNH2JAK2JAK1 | |
| SCHEMBL30005667 | 0.82 | MAP4K4 (0.50) | MAP4K4HRH3KCNH2JAK2JAK1 | |
| SCHEMBL27297116 | 0.82 | PDE4B (0.48) | MAP4K4HRH3KCNH2JAK2JAK1 | |
| SCHEMBL31086613 | 0.81 | MAP4K4 (0.49) | MAP4K4KCNH2JAK2JAK1JAK3 | |
| SCHEMBL29254937 | 0.81 | MAP4K4 (0.49) | MAP4K4KCNH2JAK2JAK1JAK3 | |
| SCHEMBL24664166 | 0.79 | MAPK1 (0.62) | MAP4K4HRH3KCNH2ALDH1A1KMT2A | |
| SCHEMBL3173071 | 0.79 | HRH3 (0.49) | MAP4K4HRH3KCNH2JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4323062-A1 | HETEROARYL AMINOPROPANOL DERIVATIVES AS INHIBITORS OF LTA4H | Novartis AG (CH) | 2024-02-21 | — | — | EP | disclosed |
| CN-117015537-A | Heteroaryl aminopropanol derivatives as inhibitors of LTA4H | 诺华股份有限公司 | 2023-11-07 | — | — | CN | disclosed |
| WO-2022219546-A1 | HETEROARYL AMINOPROPANOL DERIVATIVES AS INHIBITORS OF LTA4H | NOVARTIS AG (CH) | 2022-10-20 | — | — | WO | disclosed |