Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.42 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.41 |
| ▸ | HBB | P68871 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | MLNR | O43193 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3287232 | 1.00 | MAP4K4 (0.50) | MAP4K4HRH3KCNH2CYP19A1PTGER4 | |
| SCHEMBL5259575 | 0.92 | HRH3 (0.47) | MAP4K4HRH3KCNH2CYP19A1PTGER4 | |
| SCHEMBL29123563 | 0.82 | MAP4K4 (0.53) | MAP4K4HRH3KCNH2CYP19A1KDM4E | |
| SCHEMBL30006982 | 0.82 | MAP4K4 (0.53) | MAP4K4HRH3KCNH2CYP19A1KDM4E | |
| SCHEMBL3289972 | 0.82 | HRH3 (0.52) | MAP4K4HRH3KCNH2KDM4EMEN1 | |
| SCHEMBL16827325 | 0.81 | P2RX3 (0.47) | MAP4K4CYP19A1PDE4BLIPE | |
| SCHEMBL24664166 | 0.79 | MAPK1 (0.62) | MAP4K4HRH3KCNH2ALDH1A1KMT2A | |
| SCHEMBL3163774 | 0.79 | ALDH1A1 (0.61) | MAP4K4HRH3KCNH2KDM4EMEN1 | |
| SCHEMBL3173071 | 0.79 | HRH3 (0.49) | MAP4K4HRH3KCNH2KDM4EMEN1 | |
| SCHEMBL30731743 | 0.79 | MAPK1 (0.62) | MAP4K4HRH3KCNH2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4323062-A1 | HETEROARYL AMINOPROPANOL DERIVATIVES AS INHIBITORS OF LTA4H | Novartis AG (CH) | 2024-02-21 | — | — | EP | disclosed |
| CN-117015537-A | Heteroaryl aminopropanol derivatives as inhibitors of LTA4H | 诺华股份有限公司 | 2023-11-07 | — | — | CN | disclosed |
| WO-2022219546-A1 | HETEROARYL AMINOPROPANOL DERIVATIVES AS INHIBITORS OF LTA4H | NOVARTIS AG (CH) | 2022-10-20 | — | — | WO | disclosed |