Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 6/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.37 |
| ▸ | PDE1A | P54750 | 1/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.37 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.32 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.32 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | EDNRA | P25101 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30007192 | 0.84 | PDE7A (0.34) | PDE7APDE3APDE1APDE1BPDE4D | |
| SCHEMBL8125460 | 0.83 | PDE7A (0.49) | PDE7APDE3APDE1APDE1BPDE4D | |
| SCHEMBL30007144 | 0.83 | PDE7A (0.34) | PDE7AKMT2A | |
| SCHEMBL30007696 | 0.83 | PDE7A (0.32) | PDE7A | |
| SCHEMBL2681275 | 0.80 | PDE7A (0.61) | PDE7APDE3APDE1APDE1BPDE4D | |
| SCHEMBL29831820 | 0.80 | AGTR1 (0.34) | AGTR1PDE3AAGTR2KDM4EPKM | |
| SCHEMBL30007133 | 0.79 | PDE7A (0.36) | AGTR1PDE7APDE3APDE1APDE1B | |
| SCHEMBL8118776 | 0.79 | PDE7A (0.59) | PDE7APDE3APDE1APDE1BPDE4D | |
| SCHEMBL30007049 | 0.73 | POLB (0.32) | PDE7APDE3APDE1APDE1BPDE4D | |
| SCHEMBL30006547 | 0.73 | PDE1A (0.32) | PDE7APDE3APDE1APDE1BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115192711-A | Use of PDE7 inhibitors for the treatment of movement disorders | 奥默罗斯公司 | 2022-10-18 | — | — | CN | disclosed |