Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.45 |
| ▸ | NLRP3 | Q96P20 | 4/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.37 |
| ▸ | TCF7 | P36402 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6779647 | 0.73 | NOTUM (0.50) | NOTUMNLRP3ALDH1A1KDM4EMAPK1 | |
| SCHEMBL7592382 | 0.73 | NOTUM (0.46) | NOTUMNLRP3ALDH1A1KDM4EMAPK1 | |
| SCHEMBL3665773 | 0.73 | NOTUM (0.53) | NOTUMNLRP3ALDH1A1KDM4ECYP11B2 | |
| SCHEMBL4341894 | 0.71 | NOTUM (0.78) | NOTUMALDH1A1KDM4EMAPK1PDK2 | |
| SCHEMBL17846268 | 0.71 | NOTUM (0.44) | NOTUMNLRP3ALDH1A1KDM4EMAPK1 | |
| SCHEMBL29967049 | 0.70 | TERT (0.51) | NOTUMTRPA1ALDH1A1KDM4ECYP11B2 | |
| SCHEMBL15345059 | 0.70 | CYP11B2 (0.48) | NOTUMTRPA1ALDH1A1CYP11B2MAPT | |
| SCHEMBL24276950 | 0.70 | CYP11B2 (0.51) | TRPA1CYP11B2CDC7KCNH2CTNNB1 | |
| SCHEMBL5934873 | 0.69 | NOTUM (0.57) | NOTUMALDH1A1KDM4EMAPK1PDK2 | |
| SCHEMBL255913 | 0.69 | NOTUM (0.53) | NOTUMNLRP3ALDH1A1KDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076662-A1 | PYRAZOLYL DERIVATIVES USEFUL AS ANTI-CANCER AGENTS | Novartis AG (CH) | 2022-10-26 | — | — | EP | disclosed |