Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.61 |
| ▸ | JAK3 | P52333 | 4/20 | 0.61 |
| ▸ | JAK1 | P23458 | 1/20 | 0.61 |
| ▸ | TYK2 | P29597 | 1/20 | 0.61 |
| ▸ | PRCP | P42785 | 1/20 | 0.41 |
| ▸ | GPR55 | Q9Y2T6 | 8/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1368556 | 0.89 | JAK2 (0.64) | JAK2JAK3JAK1TYK2PRCP | |
| SCHEMBL1368552 | 0.89 | JAK2 (0.64) | JAK2JAK3JAK1TYK2PRCP | |
| Hydrochloric Acid SCHEMBL1365582 | 0.88 | JAK2 (0.62) | JAK2JAK3JAK1TYK2PRCP | |
| Hydrochloric Acid SCHEMBL1365579 | 0.88 | JAK2 (0.62) | JAK2JAK3JAK1TYK2PRCP | |
| SCHEMBL30007713 | 0.85 | JAK2 (0.53) | JAK2JAK3JAK1TYK2PRCP | |
| SCHEMBL30574675 | 0.85 | JAK2 (0.61) | JAK2JAK3JAK1TYK2PRCP | |
| SCHEMBL1366352 | 0.85 | JAK2 (0.66) | JAK2JAK3JAK1TYK2GPR55 | |
| SCHEMBL30007730 | 0.85 | JAK2 (0.66) | JAK2JAK3JAK1TYK2GPR55 | |
| SCHEMBL1368060 | 0.84 | JAK2 (0.61) | JAK2JAK3JAK1TYK2PRCP | |
| SCHEMBL1368065 | 0.84 | JAK2 (0.61) | JAK2JAK3JAK1TYK2PRCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023176972-A1 | THERAPEUTIC AGENT FOR HIGH-RISK MYELOFIBROSIS | 日本新薬株式会社 | 2023-09-21 | — | — | WO | claimed |
| WO-2023175932-A1 | THERAPEUTIC AGENT FOR HIGH-RISK MYELOFIBROSIS | 日本新薬株式会社 | 2023-09-21 | — | — | WO | claimed |
| WO-2022239068-A1 | CYTOKINE STORM INHIBITOR | 日本新薬株式会社 | 2022-11-17 | — | — | WO | claimed |
| WO-2023176972-A1 | THERAPEUTIC AGENT FOR HIGH-RISK MYELOFIBROSIS | 日本新薬株式会社 | 2023-09-21 | — | — | WO | disclosed |
| WO-2023175932-A1 | THERAPEUTIC AGENT FOR HIGH-RISK MYELOFIBROSIS | 日本新薬株式会社 | 2023-09-21 | — | — | WO | disclosed |
| WO-2022239068-A1 | CYTOKINE STORM INHIBITOR | 日本新薬株式会社 | 2022-11-17 | — | — | WO | disclosed |