Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | CLK1 | P49759 | 3/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.43 |
| ▸ | DYRK2 | Q92630 | 3/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 2/20 | 0.42 |
| ▸ | BRAF | P15056 | 3/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | ATR | Q13535 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL30007576 | 0.81 | AXL (0.54) | DYRK1APIK3CAAXLPIK3CGCAMKK2 | |
| SCHEMBL30008206 | 0.80 | CLK1 (0.43) | CLK1DYRK1AAXLBRAFATR | |
| SCHEMBL30008314 | 0.79 | AXL (0.67) | DYRK1APIK3CAAXLCAMKK2 | |
| SCHEMBL30007677 | 0.77 | AXL (0.50) | MAPK9PIK3CAAXLMAP3K11CAMKK2 | |
| SCHEMBL13854175 | 0.73 | MAPK8 (0.50) | MAPK8MAPK9MAPK10AXLBRAF | |
| SCHEMBL14616599 | 0.72 | ATR (0.52) | ATRMEN1KMT2APRKDCATM | |
| SCHEMBL30007804 | 0.72 | ALDH1A1 (0.46) | AXLBRAFCYP3A4MAP3K11 | |
| SCHEMBL27984171 | 0.71 | MAPK8 (0.47) | MAPK8MAPK9MAPK10AXLBRAF | |
| SCHEMBL14575295 | 0.71 | ATR (0.52) | CLK1DYRK1AATRPRKDCATM | |
| SCHEMBL14575030 | 0.71 | ATR (0.56) | ATRPRKDCATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022237922-A1 | ANTITUMOR COMPOUNDS BASED ON NITROGEN HETEROCYCLES AND USE THEREOF AS MEDICAMENTS | FAKULTNI NEMOCNICE HRADEC KRALOVE (CZ) | 2022-11-17 | — | — | WO | claimed |
| WO-2022237922-A1 | ANTITUMOR COMPOUNDS BASED ON NITROGEN HETEROCYCLES AND USE THEREOF AS MEDICAMENTS | FAKULTNI NEMOCNICE HRADEC KRALOVE (CZ) | 2022-11-17 | — | — | WO | disclosed |