Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.45 |
| ▸ | WNT1 | P04628 | 2/20 | 0.45 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | PRKCG | P05129 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | FES | P07332 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | ROS1 | P08922 | 1/20 | 0.43 |
| ▸ | FER | P16591 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30007248 | 0.88 | ATR (0.40) | DYRK1AWNT1GSK3BNAMPTROCK2 | |
| SCHEMBL30007902 | 0.84 | GSK3A (0.46) | DYRK1AGSK3AGSK3BAXLATR | |
| SCHEMBL30007677 | 0.83 | AXL (0.50) | KDRJAK2MAP4K4CHEK2PRKCG | |
| SCHEMBL30007878 | 0.80 | NAMPT (0.48) | KDRJAK2MAP4K4CHEK2PRKCG | |
| SCHEMBL30007738 | 0.75 | KDM5A (0.42) | GSK3AGSK3BROCK1LMNAROCK2 | |
| SCHEMBL29253947 | 0.73 | GSK3A (0.48) | DYRK1AGSK3AGSK3BJAK2PRKCG | |
| SCHEMBL30912725 | 0.73 | GSK3B (0.46) | DYRK1AGSK3AGSK3BJAK2MAP4K4 | |
| SCHEMBL30912733 | 0.73 | GSK3B (0.46) | DYRK1AGSK3AGSK3BJAK2PRKCG | |
| SCHEMBL29253946 | 0.73 | GSK3B (0.46) | DYRK1AGSK3AGSK3BJAK2MAP4K4 | |
| SCHEMBL29253944 | 0.73 | GSK3B (0.46) | DYRK1AGSK3AGSK3BJAK2PRKCG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022237922-A1 | ANTITUMOR COMPOUNDS BASED ON NITROGEN HETEROCYCLES AND USE THEREOF AS MEDICAMENTS | FAKULTNI NEMOCNICE HRADEC KRALOVE (CZ) | 2022-11-17 | — | — | WO | claimed |
| WO-2022237922-A1 | ANTITUMOR COMPOUNDS BASED ON NITROGEN HETEROCYCLES AND USE THEREOF AS MEDICAMENTS | FAKULTNI NEMOCNICE HRADEC KRALOVE (CZ) | 2022-11-17 | — | — | WO | disclosed |