SCHEMBL30007888

SCHEMBL30007888

Cc1cc2cc(C(=O)O)cc(OC(F)F)c2nn1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.35
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
CA3 P07451 1/20 0.35
PKM P14618 1/20 0.35
CA4 P22748 1/20 0.35
CA6 P23280 1/20 0.35
CA5A P35218 1/20 0.35
CA7 P43166 1/20 0.35
CA9 Q16790 1/20 0.35
CA14 Q9ULX7 1/20 0.35
CA5B Q9Y2D0 1/20 0.35
PDE4A P27815 2/20 0.33
PDE4B Q07343 2/20 0.33
PDE4C Q08493 2/20 0.33
PDE4D Q08499 2/20 0.33
SYK P43405 1/20 0.33
KDM4E B2RXH2 1/20 0.33
HTT P42858 1/20 0.33
PTGS2 P35354 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23930195 1.00 CA12 (0.35) CA12CA1CA2CA3PKM
SCHEMBL30211269 0.88 TSHR (0.34) PDE4APDE4BPDE4CPDE4DKDM4E
SCHEMBL30007783 0.86 KDM4E (0.39) CA12CA1CA2CA7CA9
SCHEMBL23930065 0.86 KDM4E (0.39) CA12CA1CA2CA7CA9
SCHEMBL23905575 0.83 HCRTR1 (0.35) CA12CA1CA2CA3PKM
SCHEMBL23904745 0.82 CA12 (0.50) CA12CA1CA2CA3PKM
SCHEMBL23905544 0.82 HCAR2 (0.37) CA12CA1CA2CA3PKM
SCHEMBL30006713 0.81 EGLN1 (0.35) CA12CA1CA2CA3PKM
SCHEMBL23958617 0.81 EGLN1 (0.35) CA12CA1CA2CA3PKM
SCHEMBL23904799 0.80 KMT2A (0.41) CA12CA1CA2CA3PKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115461336-A RSV inhibiting 3-substituted quinoline and cinnoline derivatives 爱尔兰詹森科学公司 2022-12-09 CN disclosed