Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 7/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.38 |
| ▸ | BCL9 | O00512 | 2/20 | 0.37 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23122011 | 1.00 | GFER (0.44) | GFERDDB1CRBNALDH1A1TP53 | |
| Hydrochloric Acid SCHEMBL30009428 | 0.99 | GFER (0.43) | GFERDDB1CRBNALDH1A1TP53 | |
| Hydrochloric Acid SCHEMBL23121683 | 0.99 | GFER (0.43) | GFERDDB1CRBNALDH1A1TP53 | |
| SCHEMBL28783557 | 0.91 | DDB1 (0.44) | GFERDDB1CRBNALDH1A1TP53 | |
| SCHEMBL21409448 | 0.89 | HSD11B1 (0.42) | ALDH1A1HSD11B1BCL9CTNNB1KMT2A | |
| SCHEMBL23120508 | 0.88 | MGLL (0.39) | DDB1CRBNHPGDHSD11B1BCL9 | |
| SCHEMBL29816896 | 0.88 | MGLL (0.39) | DDB1CRBNHPGDHSD11B1BCL9 | |
| Hydrochloric Acid SCHEMBL23122705 | 0.88 | HSD11B1 (0.41) | ALDH1A1HSD11B1BCL9CTNNB1KMT2A | |
| Hydrochloric Acid SCHEMBL30008988 | 0.88 | HSD11B1 (0.41) | ALDH1A1HSD11B1BCL9CTNNB1KMT2A | |
| Hydrochloric Acid SCHEMBL23121732 | 0.87 | BCL9 (0.40) | HPGDHSD11B1BCL9CTNNB1L3MBTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4041724-A1 | BRD9 BIFUNCTIONAL DEGRADERS AND THEIR METHODS OF USE | Novartis AG (CH) | 2022-08-17 | — | — | EP | disclosed |