Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1L1 | Q9UHC9 | 9/20 | 0.56 |
| ▸ | USP2 | O75604 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | CDC25A | P30304 | 5/20 | 0.54 |
| ▸ | POLA1 | P09884 | 1/20 | 0.54 |
| ▸ | VDR | P11473 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | FNTA | P49354 | 1/20 | 0.47 |
| ▸ | FNTB | P49356 | 1/20 | 0.47 |
| ▸ | INPP5D | Q92835 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acebrochol SCHEMBL1006383 | 1.00 | NPC1L1 (0.56) | NPC1L1USP2LMNAMEN1TP53 | |
| Acebrochol SCHEMBL9250494 | 1.00 | NPC1L1 (0.56) | NPC1L1USP2LMNAMEN1TP53 | |
| SCHEMBL21814362 | 0.92 | NPC1L1 (0.62) | NPC1L1USP2LMNAMEN1TP53 | |
| SCHEMBL21814361 | 0.92 | NPC1L1 (0.62) | NPC1L1USP2LMNAMEN1TP53 | |
| SCHEMBL9250800 | 0.91 | NPC1L1 (0.56) | NPC1L1USP2LMNAMEN1TP53 | |
| SCHEMBL18918658 | 0.85 | NPC1L1 (0.69) | NPC1L1USP2LMNAMEN1TP53 | |
| SCHEMBL18942513 | 0.85 | NPC1L1 (0.69) | NPC1L1USP2LMNAMEN1TP53 | |
| SCHEMBL1274095 | 0.85 | NPC1L1 (0.69) | NPC1L1USP2LMNAMEN1TP53 | |
| SCHEMBL23628419 | 0.83 | NPC1L1 (0.64) | NPC1L1USP2LMNAMEN1TP53 | |
| SCHEMBL6300889 | 0.83 | NPC1L1 (0.55) | NPC1L1USP2LMNAMEN1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115350180-A | Application of tetrabromo spiro cyclohexadienyl isoxazole compound derived from sea in preparation of medicine for treating blood tumor | 上海交通大学医学院附属仁济医院 | 2022-11-18 | — | — | CN | disclosed |