Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1L1 | Q9UHC9 | 12/20 | 0.56 |
| ▸ | OSBP | P22059 | 2/20 | 0.51 |
| ▸ | OSBP2 | Q969R2 | 2/20 | 0.51 |
| ▸ | VDR | P11473 | 3/20 | 0.51 |
| ▸ | USP2 | O75604 | 2/20 | 0.51 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.46 |
| ▸ | CDC25A | P30304 | 2/20 | 0.44 |
| ▸ | CRYAB | P02511 | 1/20 | 0.44 |
| ▸ | HMGCR | P04035 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
| ▸ | ITGAV | P06756 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.44 |
| ▸ | POLA1 | P09884 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acebrochol SCHEMBL9250494 | 0.91 | NPC1L1 (0.56) | NPC1L1VDRUSP2CDC25APOLA1 | |
| Acebrochol SCHEMBL1006383 | 0.91 | NPC1L1 (0.56) | NPC1L1VDRUSP2CDC25APOLA1 | |
| Acebrochol SCHEMBL30009744 | 0.91 | NPC1L1 (0.56) | NPC1L1VDRUSP2CDC25APOLA1 | |
| SCHEMBL18942518 | 0.86 | NPC1L1 (0.71) | NPC1L1OSBPOSBP2USP2NR1H3 | |
| SCHEMBL6393234 | 0.84 | NPC1L1 (0.56) | NPC1L1OSBPOSBP2VDRUSP2 | |
| SCHEMBL11788002 | 0.84 | NPC1L1 (0.56) | NPC1L1OSBPOSBP2VDRUSP2 | |
| SCHEMBL21814362 | 0.83 | NPC1L1 (0.62) | NPC1L1VDRUSP2CDC25APOLA1 | |
| SCHEMBL21814361 | 0.83 | NPC1L1 (0.62) | NPC1L1VDRUSP2CDC25APOLA1 | |
| SCHEMBL9250798 | 0.82 | OSBP (0.50) | NPC1L1OSBPOSBP2VDRUSP2 | |
| SCHEMBL25334068 | 0.82 | VDR (0.51) | NPC1L1VDRUSP2NR1H3POLA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5395953-A | Method of preparing hydrindane compounds and hydrindane-related compounds | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1995-03-07 | — | — | US | disclosed |
| EP-0594229-A1 | Method of preparing hydrindane compounds and hydrindane-related compounds | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1994-04-27 | — | — | EP | disclosed |