Acebrochol

Acebrochol

SCHEMBL1006383

CC(=O)O[C@H]1CC[C@]2(C)C3CC[C@@]4(C)C(CC[C@@H]4[C@H](C)CCCC(C)C)C3C[C@@H](Br)[C@@]2(Br)C1

nearest known ligand 0.56

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ NPC1L1 Q9UHC9 9/20 0.56
▸ USP2 O75604 3/20 0.54
▸ LMNA P02545 2/20 0.54
▸ MEN1 O00255 1/20 0.54
▸ TP53 P04637 1/20 0.54
▸ KMT2A Q03164 1/20 0.54
▸ CDC25A P30304 5/20 0.54
▸ POLA1 P09884 1/20 0.54
▸ VDR P11473 1/20 0.53
▸ NPC1 O15118 1/20 0.51
▸ CYP2D6 P10635 1/20 0.47
▸ CYP2C19 P33261 1/20 0.47
▸ FNTA P49354 1/20 0.47
▸ FNTB P49356 1/20 0.47
▸ INPP5D Q92835 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acebrochol SCHEMBL9250494 1.00 NPC1L1 (0.56) NPC1L1USP2LMNAMEN1TP53
Acebrochol SCHEMBL30009744 1.00 NPC1L1 (0.56) NPC1L1USP2LMNAMEN1TP53
SCHEMBL21814362 0.92 NPC1L1 (0.62) NPC1L1USP2LMNAMEN1TP53
SCHEMBL21814361 0.92 NPC1L1 (0.62) NPC1L1USP2LMNAMEN1TP53
SCHEMBL9250800 0.91 NPC1L1 (0.56) NPC1L1USP2LMNAMEN1TP53
SCHEMBL18918658 0.85 NPC1L1 (0.69) NPC1L1USP2LMNAMEN1TP53
SCHEMBL18942513 0.85 NPC1L1 (0.69) NPC1L1USP2LMNAMEN1TP53
SCHEMBL1274095 0.85 NPC1L1 (0.69) NPC1L1USP2LMNAMEN1TP53
SCHEMBL23628419 0.83 NPC1L1 (0.64) NPC1L1USP2LMNAMEN1TP53
SCHEMBL6300889 0.83 NPC1L1 (0.55) NPC1L1USP2LMNAMEN1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 124 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250032510-A1 AMORPHOUS SOLID DISPERSION GANAXOLONE FORMULATION IMMEDICA PHARMA US INC. 2025-01-30 — — US claimed
WO-2023060067-A1 AMORPHOUS SOLID DISPERSION GANAXOLONE FORMULATION MARINUS PHARMACEUTICALS, INC. (US) 2023-04-13 — — WO claimed
US-20220023314-A1 STABLE FORMULATIONS OF ANESTHETICS AND ASSOCIATED DOSAGE FORMS Halo Science LLC 2022-01-27 — — US claimed
EP-3893847-A1 STABLE FORMULATIONS OF ANESTHETICS AND ASSOCIATED DOSAGE FORMS Halo Science LLC (US) 2021-10-20 — — EP claimed
WO-2020123551-A1 STABLE FORMULATIONS OF ANESTHETICS AND ASSOCIATED DOSAGE FORMS Halo Science LLC (US) 2020-06-18 — — WO claimed
CN-110520131-A The neurosteroid preparation of sustained release injectable MARINUS PHARMACEUTICALS INC 2019-11-29 — — CN claimed
US-20190321375-A1 METHOD OF ADMINISTERING A NEUROSTEROID TO EFFECT ELECTROENCEPHALOGRAPHIC (EEG) BURST SUPPRESSION MARINUS PHARMACEUTICALS INC (US) 2019-10-24 — — US claimed
EP-3525797-A1 METHOD OF ADMINISTERING A NEUROSTEROID TO EFFECT ELECTROENCEPHALOGRAPHIC (EEG) BURST SUPPRESSION Marinus Pharmaceuticals, Inc. (US) 2019-08-21 — — EP claimed
CN-109890392-A Method of the application neurosteroid to realize electroencephalogram (EEG) outburst inhibition 马瑞纳斯制药公司 2019-06-14 — — CN claimed
US-20180296487-A1 SUSTAINED RELEASE INJECTABLE NEUROSTEROID FORMULATIONS MARINUS PHARMACEUTICALS INC (US) 2018-10-18 — — US claimed
US-8975245-B2 Anaesthetic formulation DRAWBRIDGE PHARMACEUTICALS PTY LTD (AU) 2015-03-10 — — US claimed
US-20140066417-A1 ANAESTHETIC FORMULATION DRAWBRIDGE PHARMACEUTICALS PTY LTD (AU) 2014-03-06 — — US claimed
US-20120316146-A1 ANAESTHETIC FORMULATION MONASH UNIVERSITY (AU) 2012-12-13 — — US claimed
CN-102802635-A Anaesthetic formulation GOODCHILD INVEST PTY LTD 2012-11-28 — — CN claimed
WO-2011088503-A1 ANAESTHETIC FORMULATION GOODCHILD INVESTMENTS PTY LTD (AU) 2011-07-28 — — WO claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 — — US claimed
CN-101330905-A Freeze-drying process and products obtained thereby SCIDOSE LLC (US) 2008-12-24 — — CN claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 — — EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 — — WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 — — US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190321375-A1 METHOD OF ADMINISTERING A NEUROSTEROID TO EFFECT ELECTROENCEPHALOGRAPHIC (EEG) BURST SUPPRESSION SCN11A, SCN10A, PYGB NPC1L1 2469/4885USP2 2258/4885LMNA 2743/4885
US-20180296487-A1 SUSTAINED RELEASE INJECTABLE NEUROSTEROID FORMULATIONS SCN10A, THRA, TSHR NPC1L1 1573/4885USP2 3527/4885LMNA 2060/4885
US-20120316146-A1 ANAESTHETIC FORMULATION OPRL1, CNR1, CNR2 NPC1L1 430/4885USP2 3071/4885LMNA 4560/4885
US-20140066417-A1 ANAESTHETIC FORMULATION OPRL1, CNR1, CNR2 NPC1L1 430/4885USP2 3071/4885LMNA 4560/4885
US-20250032510-A1 AMORPHOUS SOLID DISPERSION GANAXOLONE FORMULATION PYGB, GYS2, CYP21A2 NPC1L1 624/4885USP2 1757/4885LMNA 3549/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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