Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 1/20 | 0.51 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.51 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.47 |
| ▸ | LOX | P28300 | 1/20 | 0.46 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.43 |
| ▸ | IDH2 | P48735 | 4/20 | 0.42 |
| ▸ | IDH1 | O75874 | 3/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9234478 | 1.00 | SMARCA2 (0.51) | SMARCA2SMARCA4LOXL2LOXTAS2R14 | |
| SCHEMBL22601563 | 0.82 | PRKCI (0.49) | SMARCA2SMARCA4IDH2IDH1HDAC4 | |
| SCHEMBL27893424 | 0.80 | KIF11 (0.53) | LOXL2NOTUM | |
| SCHEMBL2479367 | 0.80 | LOXL2 (0.52) | SMARCA2SMARCA4LOXL2LOXTAS2R14 | |
| SCHEMBL30505955 | 0.80 | LOXL2 (0.52) | SMARCA2SMARCA4LOXL2LOXTAS2R14 | |
| SCHEMBL23639222 | 0.80 | SMARCA2 (0.51) | SMARCA2SMARCA4LOXL2LOXTAS2R14 | |
| SCHEMBL25124381 | 0.79 | SMARCA2 (0.48) | SMARCA2SMARCA4LOXL2LOXTAS2R14 | |
| Hydrochloric Acid SCHEMBL16633226 | 0.78 | LOXL2 (0.53) | SMARCA2SMARCA4LOXL2LOXTAS2R14 | |
| Hydrochloric Acid SCHEMBL31696645 | 0.78 | LOXL2 (0.53) | SMARCA2SMARCA4LOXL2LOXTAS2R14 | |
| SCHEMBL24258152 | 0.77 | SMARCA2 (0.64) | SMARCA2SMARCA4HDAC4HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113264945-B | Spiro derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2022-11-22 | — | — | CN | disclosed |