Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | CASP7 | P55210 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA7 | P43166 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30015077 | 0.80 | ACACB (0.38) | KDM4EHTT | |
| SCHEMBL30016744 | 0.80 | — | — | |
| SCHEMBL28634036 | 0.78 | RAF1 (0.34) | — | |
| SCHEMBL30016918 | 0.78 | RAF1 (0.34) | — | |
| SCHEMBL30016109 | 0.75 | KDM4E (0.42) | KDM4EHTTATMHSD11B1ALDH1A1 | |
| SCHEMBL28628147 | 0.74 | CA1 (0.48) | KDM4EHTTATMALDH1A1HPGD | |
| SCHEMBL1819491 | 0.71 | KDM4E (0.54) | KDM4EHTTATMALDH1A1HPGD | |
| SCHEMBL4346066 | 0.69 | HSD11B1 (0.45) | KDM4EHTTATMHSD11B1 | |
| SCHEMBL27203838 | 0.68 | MAOB (0.37) | HTT | |
| SCHEMBL28636275 | 0.68 | RAF1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113264945-B | Spiro derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2022-11-22 | — | — | CN | disclosed |