Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.41 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24770251 | 1.00 | BAZ2B (0.41) | BAZ2BBAZ2AKMT2AMEN1PDCD1 | |
| SCHEMBL24769643 | 0.82 | PDCD1 (0.41) | KMT2AMEN1PDCD1CD274ALDH1A1 | |
| SCHEMBL24770297 | 0.77 | BAZ2B (0.42) | BAZ2BBAZ2AKMT2AMEN1MAPT | |
| SCHEMBL24770186 | 0.76 | BAZ2B (0.48) | BAZ2BBAZ2AKMT2AMEN1MAPT | |
| SCHEMBL22717325 | 0.76 | BAZ2B (0.48) | BAZ2BBAZ2AKMT2AMEN1MAPT | |
| SCHEMBL29198963 | 0.72 | PDCD1 (0.40) | KMT2AMEN1PDCD1CD274MAPK10 | |
| SCHEMBL24769352 | 0.72 | BAZ2B (0.44) | BAZ2BBAZ2AKMT2AMEN1MAPT | |
| SCHEMBL3652621 | 0.72 | BAZ2B (0.51) | BAZ2BBAZ2AKMT2AMEN1MAPT | |
| SCHEMBL190973 | 0.72 | BAZ2B (0.51) | BAZ2BBAZ2AKMT2AMEN1MAPT | |
| SCHEMBL29574609 | 0.72 | BAZ2B (0.51) | BAZ2BBAZ2AKMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4352055-A1 | O-LINKED THIADIAZOLYL COMPOUNDS AS DNA POLYMERASE THETA INHIBITORS | Ideaya Biosciences, Inc. (US) | 2024-04-17 | — | — | EP | disclosed |
| WO-2022259204-A1 | O-LINKED THIADIAZOLYL COMPOUNDS AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2022-12-15 | — | — | WO | disclosed |