Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.44 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24770297 | 0.79 | BAZ2B (0.42) | BAZ2BBAZ2AALDH1A1MAPTHPGD | |
| SCHEMBL25232131 | 0.78 | DPP4 (0.41) | ALDH1A1HPGDKMT2AMEN1KDM4E | |
| SCHEMBL31523353 | 0.78 | BAZ2B (0.44) | BAZ2BBAZ2AALDH1A1MAPTHPGD | |
| SCHEMBL31208511 | 0.78 | DPP4 (0.41) | ALDH1A1HPGDKMT2AMEN1KDM4E | |
| SCHEMBL24769645 | 0.78 | POLQ (0.61) | ALDH1A1KDM4ENPSR1 | |
| SCHEMBL190973 | 0.78 | BAZ2B (0.51) | BAZ2BBAZ2AALDH1A1MAPTHPGD | |
| SCHEMBL3652621 | 0.78 | BAZ2B (0.51) | BAZ2BBAZ2AALDH1A1MAPTHPGD | |
| SCHEMBL29574609 | 0.78 | BAZ2B (0.51) | BAZ2BBAZ2AALDH1A1MAPTHPGD | |
| SCHEMBL5741519 | 0.76 | CYP1A2 (0.55) | ALDH1A1MAPTHPGDTDP1KMT2A | |
| SCHEMBL26984412 | 0.76 | ALDH1A1 (0.51) | ALDH1A1MAPTHPGDKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117794927-A | O-linked thiadiazolyl compounds as inhibitors of DNA polymerase theta | 伊迪亚生物科学有限公司 | 2024-03-29 | — | — | CN | disclosed |
| WO-2022259204-A1 | O-LINKED THIADIAZOLYL COMPOUNDS AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2022-12-15 | — | — | WO | disclosed |