SCHEMBL30020768

SCHEMBL30020768

COC(=O)c1cccc(Nc2nc(N3CCC[C@H](NC(=O)OC(C)(C)C)C3)ncc2C(N)=O)c1

nearest known ligand 0.65

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ BTK Q06187 1/20 0.65
▸ CAMK1D Q8IU85 19/20 0.60
▸ MAP3K7 O43318 1/20 0.55
▸ CSF1R P07333 1/20 0.55
▸ PIM1 P11309 1/20 0.55
▸ MAPK3 P27361 1/20 0.55
▸ MAPK1 P28482 1/20 0.55
▸ SYK P43405 1/20 0.55
▸ BLK P51451 1/20 0.55
▸ RIPK4 P57078 1/20 0.55
▸ CSNK2A1 P68400 1/20 0.55
▸ KCNH2 Q12809 1/20 0.55
▸ MAP2K5 Q13163 1/20 0.55
▸ MAP3K11 Q16584 1/20 0.55
▸ AURKB Q96GD4 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23113253 0.93 CAMK1D (0.60) BTKCAMK1DMAP3K7CSF1RPIM1
SCHEMBL23113255 0.93 CAMK1D (0.60) BTKCAMK1DMAP3K7CSF1RPIM1
SCHEMBL28903909 0.90 CAMK1D (0.60) BTKCAMK1D
SCHEMBL30022978 0.89 CAMK1D (0.60) BTKCAMK1DMAP3K7CSF1RPIM1
SCHEMBL30022992 0.89 CAMK1D (0.64) BTKCAMK1D
SCHEMBL23113624 0.89 BTK (0.62) BTKCAMK1DKCNH2MAP2K5MAP3K11
SCHEMBL23113625 0.89 BTK (0.62) BTKCAMK1DKCNH2MAP2K5MAP3K11
SCHEMBL30022892 0.89 CAMK1D (0.76) BTKCAMK1DMAP3K7CSF1RPIM1
SCHEMBL23113503 0.88 CAMK1D (0.65) BTKCAMK1D
SCHEMBL30022450 0.87 CAMK1D (0.73) BTKCAMK1DMAP3K7CSF1RPIM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11530193-B2 Kinase inhibitors THE UNIVERSITY OF MANCHESTER (GB) 2022-12-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11530193-B2 Kinase inhibitors CAMKK2, CAMK1, CAMKK1 BTK 1532/4885CAMK1D 5/4885MAP3K7 33/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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