Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 11/20 | 0.66 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.53 |
| ▸ | FAAH | O00519 | 2/20 | 0.53 |
| ▸ | GPX4 | P36969 | 1/20 | 0.52 |
| ▸ | CDK4 | P11802 | 3/20 | 0.50 |
| ▸ | CCND1 | P24385 | 3/20 | 0.50 |
| ▸ | MTHFD2 | P13995 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5367984 | 1.00 | PARP1 (0.66) | PARP1TRPV1FAAHGPX4CDK4 | |
| SCHEMBL8359246 | 0.84 | PARP1 (0.68) | PARP1TRPV1GPX4 | |
| SCHEMBL969392 | 0.84 | TRPV1 (0.72) | TRPV1FAAHGPX4CDK4CCND1 | |
| SCHEMBL8360520 | 0.84 | PARP1 (0.71) | PARP1TRPV1FAAHGPX4CDK4 | |
| SCHEMBL8360521 | 0.83 | PARP1 (0.73) | PARP1TRPV1GPX4 | |
| SCHEMBL8360509 | 0.82 | PARP1 (0.69) | PARP1TRPV1GPX4 | |
| SCHEMBL8360524 | 0.82 | PARP1 (0.58) | PARP1TRPV1FAAHGPX4CDK4 | |
| SCHEMBL2270578 | 0.81 | PARP1 (0.57) | PARP1TRPV1FAAHGPX4CDK4 | |
| SCHEMBL8363099 | 0.81 | PARP1 (0.67) | PARP1TRPV1FAAHGPX4CDK4 | |
| SCHEMBL8360518 | 0.80 | PARP1 (0.56) | PARP1TRPV1FAAHGPX4CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076648-A1 | SUBSTITUTED BICYCLIC AND TRICYCLIC UREAS AND AMIDES, ANALOGUES THEREOF, AND METHODS USING SAME | Arbutus Biopharma Corporation (CA) | 2022-10-26 | — | — | EP | disclosed |