Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 5/20 | 0.44 |
| ▸ | BRS3 | P32247 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 2/20 | 0.41 |
| ▸ | CDK8 | P49336 | 2/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | LYN | P07948 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30025269 | 0.79 | TYK2 (0.40) | FEN1PDK2BRS3ROCK1METAP2 | |
| SCHEMBL31182236 | 0.76 | METAP2 (0.50) | PDK2LCKBTKMETAP2 | |
| SCHEMBL30024452 | 0.75 | BRS3 (0.39) | PDK2BRS3MAP4K4FGFR1FGFR3 | |
| SCHEMBL30024480 | 0.72 | JAK2 (0.45) | FFAR1ALOX5APFEN1PDK2BRS3 | |
| SCHEMBL21776728 | 0.72 | JAK2 (0.45) | FFAR1ALOX5APFEN1PDK2BRS3 | |
| SCHEMBL30025242 | 0.72 | KDM4E (0.41) | PDK2BRS3CDK8LRRK2METAP2 | |
| SCHEMBL30331919 | 0.72 | PIM1 (0.45) | FFAR1ALOX5APFEN1PDK2MAP4K4 | |
| SCHEMBL30332524 | 0.72 | CCNT1 (0.47) | FFAR1ALOX5APFEN1PDK2MAP4K4 | |
| SCHEMBL22612487 | 0.70 | KIT (0.42) | PDK2MAP4K4METCDK8PLK4 | |
| SCHEMBL21938590 | 0.70 | CREBBP (0.56) | FFAR1ALOX5APFEN1PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110862375-B | Pyrazole compound and pharmaceutical composition and application thereof | 深圳铂立健医药有限公司 | 2022-10-25 | — | — | CN | disclosed |