Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 14/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19569459 | 1.00 | ATF4 (0.50) | ATF4SMN1; SMN2GPR34FFAR1FFAR4 | |
| SCHEMBL19569203 | 0.92 | ATF4 (0.59) | ATF4SMN1; SMN2GPR34 | |
| SCHEMBL19569457 | 0.89 | ATF4 (0.53) | ATF4 | |
| SCHEMBL19555442 | 0.87 | ATF4 (0.55) | ATF4MRGPRX4 | |
| SCHEMBL30026324 | 0.87 | ATF4 (0.55) | ATF4MRGPRX4 | |
| SCHEMBL30025703 | 0.85 | ATF4 (0.50) | ATF4MRGPRX4 | |
| SCHEMBL19569469 | 0.85 | ATF4 (0.50) | ATF4MRGPRX4 | |
| SCHEMBL19555463 | 0.82 | ATF4 (0.65) | ATF4 | |
| SCHEMBL19569210 | 0.81 | ATF4 (0.61) | ATF4 | |
| SCHEMBL19569461 | 0.80 | ATF4 (0.53) | ATF4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115947681-A | Modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2023-04-11 | — | — | CN | disclosed |
| CN-109641844-B | Modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2022-11-01 | — | — | CN | disclosed |