Sugi Predict

Sugi Predict / Compounds / SCHEMBL30026366

SCHEMBL30026366

SCHEMBL30026366

Nc1ncccc1-c1cc(Cc2ccc(Oc3cc(F)cc(F)n3)cc2)no1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ JAK2 O60674 2/20 0.35
▸ ROCK2 O75116 2/20 0.35
▸ PRKACA P17612 2/20 0.35
▸ CDK2 P24941 2/20 0.35
▸ KDR P35968 2/20 0.35
▸ GSK3B P49841 2/20 0.35
▸ AURKB Q96GD4 2/20 0.35
▸ CDC7 O00311 1/20 0.35
▸ MAP4K4 O95819 1/20 0.35
▸ PAK4 O96013 1/20 0.35
▸ PIM1 P11309 1/20 0.35
▸ HIPK2 Q9H2X6 1/20 0.35
▸ CLK4 Q9HAZ1 1/20 0.35
▸ MKNK2 Q9HBH9 1/20 0.35
▸ IRAK4 Q9NWZ3 1/20 0.35
▸ ALDH1A1 P00352 1/20 0.34
▸ RAB9A P51151 1/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ TDP1 Q9NUW8 1/20 0.34
▸ L3MBTL1 Q9Y468 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21054528 1.00 JAK2 (0.35) JAK2ROCK2PRKACACDK2KDR
SCHEMBL21054758 0.90 CHRM5 (0.36) JAK2ROCK2PRKACACDK2KDR
SCHEMBL30026258 0.90 CHRM5 (0.36) JAK2ROCK2PRKACACDK2KDR
SCHEMBL25086733 0.89 JAK2 (0.37) JAK2ROCK2PRKACACDK2KDR
SCHEMBL21054520 0.86 MEN1 (0.39) JAK2ROCK2PRKACACDK2KDR
SCHEMBL511304 0.85 RAB9A (0.40) JAK2ROCK2PRKACACDK2KDR
SCHEMBL30026059 0.85 RAB9A (0.40) JAK2ROCK2PRKACACDK2KDR
SCHEMBL510467 0.84 MEN1 (0.42) JAK2ROCK2PRKACACDK2KDR
SCHEMBL30026560 0.84 MEN1 (0.42) JAK2ROCK2PRKACACDK2KDR
SCHEMBL510934 0.84 TNK2 (0.40) JAK2ROCK2PRKACACDK2KDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250101012-A1 HETEROCYCLE SUBSTITUTED PYRIDINE DERIVATIVE ANTIFUNGAL AGENTS BASILEA PHARMACEUTICA INTERNATIONAL AG, ALLSCHWIL (CH) 2025-03-27 — — US disclosed
US-12139479-B2 Heterocycle substituted pyridine derivative antifungal agents BASILEA PHARMACEUTICA INTERNATIONAL AG, ALLSCHWIL (CH) 2024-11-12 — — US disclosed
CN-111698989-B Heterocyclic substituted pyridine derivatives as antifungal agents 安普利克斯制药公司 2023-08-01 — — CN disclosed
US-20230065881-A1 HETEROCYCLE SUBSTITUTED PYRIDINE DERIVATIVE ANTIFUNGAL AGENTS AMPLYX PHARMACEUTICALS, INC. (US) 2023-03-02 — — US disclosed
US-11512079-B2 Heterocycle substituted pyridine derivative antifungal agents AMPLYX PHARMACEUTICALS, INC. (US) 2022-11-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250101012-A1 HETEROCYCLE SUBSTITUTED PYRIDINE DERIVATIVE ANTIFUNGAL AGENTS ERG28, DPM1, CYP51A1 JAK2 1733/4885ROCK2 3799/4885PRKACA 269/4885
US-20230065881-A1 HETEROCYCLE SUBSTITUTED PYRIDINE DERIVATIVE ANTIFUNGAL AGENTS ERG28, DPM1, CYP51A1 JAK2 1733/4885ROCK2 3799/4885PRKACA 269/4885
US-12139479-B2 Heterocycle substituted pyridine derivative antifungal agents ERG28, DPM1, CYP51A1 JAK2 1733/4885ROCK2 3799/4885PRKACA 269/4885
US-11512079-B2 Heterocycle substituted pyridine derivative antifungal agents ERG28, DPM1, CYP51A1 JAK2 1733/4885ROCK2 3799/4885PRKACA 269/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.