Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ASPH | Q12797 | 2/20 | 0.47 |
| ▸ | KDM8 | Q8N371 | 2/20 | 0.47 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.35 |
| ▸ | WNT3A | P56704 | 2/20 | 0.35 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | KDM5A | P29375 | 2/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10713223 | 0.84 | KDM4E (0.37) | KDM4EASPHKDM8PARP1HTT | |
| SCHEMBL30798651 | 0.79 | PARP1 (0.37) | KDM4EASPHKDM8PARP1HTT | |
| SCHEMBL2425108 | 0.79 | CYP19A1 (0.39) | KDM4EPARP1HTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL18226070 | 0.79 | PARP1 (0.37) | KDM4EASPHKDM8PARP1HTT | |
| SCHEMBL453513 | 0.75 | KEAP1 (0.49) | KDM4ENAPRTPARP1HTTSMN1; SMN2 | |
| SCHEMBL29743300 | 0.74 | CHEK2 (0.36) | KDM4CHSD17B1HSD17B2 | |
| SCHEMBL5990597 | 0.74 | KEAP1 (0.47) | KDM4ENAPRTPARP1HTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL22165595 | 0.74 | KEAP1 (0.47) | KDM4ENAPRTPARP1HTTSMN1; SMN2 | |
| SCHEMBL1193119 | 0.74 | PARP1 (0.39) | KDM4EPARP1ALDH1A1 | |
| SCHEMBL29804759 | 0.74 | PARP1 (0.39) | KDM4EPARP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4271674-A1 | CARBOXY-BENZIMIDAZOLE GLP-1R MODULATING COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2023-11-08 | — | — | EP | disclosed |
| WO-2022225914-A1 | CARBOXY-BENZIMIDAZOLE GLP-1R MODULATING COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2022-10-27 | — | — | WO | disclosed |