Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.35 |
| ▸ | WNT3A | P56704 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | KMO | O15229 | 2/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18226070 | 1.00 | PARP1 (0.37) | PARP1HTTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL10713223 | 0.81 | KDM4E (0.37) | PARP1HTTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL6137710 | 0.79 | DPP4 (0.44) | PARP1HTTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL30028461 | 0.79 | KDM4E (0.47) | PARP1HTTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL1193119 | 0.77 | PARP1 (0.39) | PARP1KDM4EALDH1A1MAPT | |
| SCHEMBL29804759 | 0.77 | PARP1 (0.39) | PARP1KDM4EALDH1A1MAPT | |
| SCHEMBL3525912 | 0.72 | HAO1 (0.33) | ALDH1A1 | |
| SCHEMBL29894129 | 0.72 | PARP1 (0.42) | PARP1HTTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL13544495 | 0.72 | PARP1 (0.42) | PARP1HTTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL1374558 | 0.70 | PRKCI (0.44) | PARP1SMN1; SMN2KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113166156-B | Tyrosine kinase inhibitors, compositions and methods | 贝达药业股份有限公司 | 2024-02-27 | — | — | CN | claimed |
| CN-113166156-B | Tyrosine kinase inhibitors, compositions and methods | 贝达药业股份有限公司 | 2024-02-27 | — | — | CN | disclosed |