SCHEMBL300286

SCHEMBL300286

O=C(O)C(CO)Nc1ccc(O)c(O)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ERCC1 P07992 1/20 0.46
ERCC4 Q92889 1/20 0.46
CA2 P00918 7/20 0.41
CA1 P00915 6/20 0.41
KDM6B O15054 1/20 0.41
CA12 O43570 2/20 0.40
CA9 Q16790 2/20 0.40
CA14 Q9ULX7 2/20 0.40
KDM4E B2RXH2 8/20 0.40
HSD17B10 Q99714 5/20 0.40
TDP1 Q9NUW8 5/20 0.40
HIF1A Q16665 4/20 0.40
RECQL P46063 2/20 0.40
PTGS2 P35354 2/20 0.40
USP2 O75604 1/20 0.40
EGFR P00533 1/20 0.40
LCK P06239 1/20 0.40
FYN P06241 1/20 0.40
ADORA3 P0DMS8 1/20 0.40
ALOX15 P16050 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL300287 1.00 ERCC1 (0.46) ERCC1ERCC4CA2CA1KDM6B
Hydrochloric Acid SCHEMBL15266596 0.98 ERCC1 (0.45) ERCC1ERCC4CA2CA1KDM6B
SCHEMBL2283372 0.85 GAA (0.42) ERCC1ERCC4CA2CA1KDM6B
SCHEMBL4159980 0.82 TSHR (0.49) CA2CA1CA12CA9CA14
SCHEMBL4159978 0.82 TSHR (0.49) CA2CA1CA12CA9CA14
SCHEMBL29051409 0.81 PPARG (0.50) ERCC1ERCC4CA2CA1NPSR1
SCHEMBL30467554 0.81 PPARG (0.50) ERCC1ERCC4CA2CA1NPSR1
SCHEMBL18144294 0.80 CA2 (0.44) CA2CA1CA12CA9CA14
SCHEMBL1794244 0.80 CA2 (0.44) CA2CA1CA12CA9CA14
SCHEMBL31540140 0.80 CA2 (0.47) ERCC1ERCC4CA2CA1KDM6B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117305198-A Recombinant bacterium and application thereof in synthesis of L-3, 4-dihydroxyphenylalanine 杭州唯铂莱生物科技有限公司 2023-12-29 CN claimed
EP-0920307-A2 DERIVATES FROM BISARYLTETRACARBONACID, AND PHARMARCEUTICAL PRODUCT CONTAINING THEM Roche Diagnostics GmbH (DE) 1999-06-09 EP claimed
WO-1998006386-A2 DERIVATES FROM BISARYLTETRACARBONACID, AND PHARMARCEUTICAL PRODUCT CONTAINING THEM ROCHE DIAGNOSTICS GMBH (DE) 1998-02-19 WO claimed
EP-0580409-A2 Cosmetic composition containing DOPA derivatives UNILEVER PLC (GB) 1994-01-26 EP claimed
US-4529603-A Erythro-3,4-dihydroxyphenylserine SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1985-07-16 US claimed
US-4497826-A THREO-3,4-DIHYDROXYPHENYLSERINE, CARBIDOPA AND BENSERAZIDE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1985-02-05 US claimed
JP-58052219-A None JP disclosed
JP-7278073-A None JP disclosed
JP-7278074-A None JP disclosed
JP-7278075-A None JP disclosed
JP-6157251-A None JP disclosed
US-11904014-B2 Immunostimulatory compositions Assistance Publique—Hopitaux de Paris (FR) 2024-02-20 US disclosed
CN-117305198-A Recombinant bacterium and application thereof in synthesis of L-3, 4-dihydroxyphenylalanine 杭州唯铂莱生物科技有限公司 2023-12-29 CN disclosed
JP-H06157251-A COSMETIC COMPOSITION UNILEVER NV 1994-06-03 JP disclosed
EP-0580409-A2 Cosmetic composition containing DOPA derivatives UNILEVER PLC (GB) 1994-01-26 EP disclosed
EP-0218440-A3 N-METHYLPHENYLSERINE ALKYL ESTER DERIVATIVES AND USES THEREOF ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) 1988-01-13 EP disclosed
US-4690949-A ADMINISTERING 3,4-DIHYDROXYPHENYLSERINE SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 1987-09-01 US disclosed
EP-0218440-A2 N-Methylphenylserine alkyl ester derivatives and uses thereof ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) 1987-04-15 EP disclosed
US-4497826-A THREO-3,4-DIHYDROXYPHENYLSERINE, CARBIDOPA AND BENSERAZIDE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1985-02-05 US disclosed
JP-S5852219-A REMEDY FOR PARKINSON'S DISEASE (PERKINSONISM) SUMITOMO CHEM CO LTD 1983-03-28 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11904014-B2 Immunostimulatory compositions CD47, CD74, LY96 ERCC1 621/4885ERCC4 570/4885CA2 2331/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.