Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 15/20 | 0.81 |
| ▸ | CRBN | Q96SW2 | 15/20 | 0.81 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20805490 | 0.90 | DDB1 (1.00) | DDB1CRBNGPR119 | |
| SCHEMBL29984027 | 0.90 | DDB1 (1.00) | DDB1CRBNGPR119 | |
| SCHEMBL30794089 | 0.88 | DDB1 (0.74) | DDB1CRBNGPR119 | |
| SCHEMBL30793998 | 0.88 | DDB1 (0.74) | DDB1CRBNGPR119 | |
| SCHEMBL24530623 | 0.87 | CRBN (0.61) | DDB1CRBN | |
| SCHEMBL31554657 | 0.87 | DDB1 (0.80) | DDB1CRBN | |
| SCHEMBL30029251 | 0.87 | CRBN (0.66) | DDB1CRBN | |
| SCHEMBL24754186 | 0.87 | CRBN (0.66) | DDB1CRBN | |
| SCHEMBL26259198 | 0.86 | CRBN (0.60) | DDB1CRBN | |
| SCHEMBL30661527 | 0.85 | DDB1 (0.80) | DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022266248-A1 | SOS1 PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. (US) | 2022-12-22 | — | — | WO | disclosed |
| WO-2022266249-A1 | KRAS PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. (US) | 2022-12-22 | — | — | WO | disclosed |