Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | REN | P00797 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23577961 | 1.00 | KDM4E (0.49) | KDM4EALDH1A1TSHRRENTHRB | |
| SCHEMBL30036618 | 0.90 | KDM4E (0.52) | KDM4EALDH1A1TSHRMAPTGAA | |
| SCHEMBL28965596 | 0.90 | KDM4E (0.52) | KDM4EALDH1A1TSHRMAPTGAA | |
| SCHEMBL25387698 | 0.83 | KDM4E (0.48) | KDM4EALDH1A1TSHRMAPTGAA | |
| SCHEMBL23577653 | 0.83 | KDM4E (0.48) | KDM4EALDH1A1TSHRHSD17B10PLK1 | |
| SCHEMBL30036279 | 0.83 | KDM4E (0.48) | KDM4EALDH1A1TSHRHSD17B10PLK1 | |
| SCHEMBL23578383 | 0.83 | KDM4E (0.56) | KDM4EALDH1A1TSHRMAPTGAA | |
| SCHEMBL30034996 | 0.83 | KDM4E (0.56) | KDM4EALDH1A1TSHRMAPTGAA | |
| SCHEMBL29267734 | 0.83 | TSHR (0.44) | KDM4EALDH1A1TSHRTHRBKMO | |
| SCHEMBL17934375 | 0.82 | EGFR (0.48) | KDM4EALDH1A1CYP3A4CYP2C19CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115605476-A | Substituted tricyclic compounds | 鲁宾有限公司（IN） | 2023-01-13 | — | — | CN | disclosed |
| EP-4081521-A1 | SUBSTITUTED TRICYCLIC COMPOUNDS | Lupin Limited (IN) | 2022-11-02 | — | — | EP | disclosed |