Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28965596 | 1.00 | KDM4E (0.52) | KDM4EALDH1A1HTTUSP2PLK1 | |
| SCHEMBL30036330 | 0.90 | KDM4E (0.49) | KDM4EALDH1A1HTTPLK1TSHR | |
| SCHEMBL23577961 | 0.90 | KDM4E (0.49) | KDM4EALDH1A1HTTPLK1TSHR | |
| SCHEMBL30036279 | 0.86 | KDM4E (0.48) | KDM4EALDH1A1HTTUSP2PLK1 | |
| SCHEMBL25387698 | 0.86 | KDM4E (0.48) | KDM4EALDH1A1HTTUSP2PLK1 | |
| SCHEMBL23577653 | 0.86 | KDM4E (0.48) | KDM4EALDH1A1HTTUSP2PLK1 | |
| SCHEMBL25387443 | 0.86 | HTT (0.42) | ALDH1A1HTTUSP2PLK1TSHR | |
| SCHEMBL30514071 | 0.86 | HTT (0.45) | KDM4EALDH1A1HTTUSP2PLK1 | |
| SCHEMBL23578383 | 0.84 | KDM4E (0.56) | KDM4EALDH1A1TSHRGAAMAPT | |
| SCHEMBL30034996 | 0.84 | KDM4E (0.56) | KDM4EALDH1A1TSHRGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4081521-A1 | SUBSTITUTED TRICYCLIC COMPOUNDS | Lupin Limited (IN) | 2022-11-02 | — | — | EP | disclosed |