Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30183714 | 0.90 | ALDH1A1 (0.43) | TSHRKDM4ESIRT6POLBMAPT | |
| SCHEMBL23590845 | 0.90 | ALDH1A1 (0.43) | TSHRKDM4ESIRT6POLBMAPT | |
| SCHEMBL23577603 | 0.85 | MAPT (0.45) | KDM4ESIRT6POLBMAPTRECQL | |
| SCHEMBL30183974 | 0.84 | KDM4E (0.39) | TSHRKDM4ESIRT6POLBMAPT | |
| SCHEMBL25387167 | 0.84 | CTRC (0.38) | TSHRKDM4ESIRT6POLBMAPT | |
| SCHEMBL17934416 | 0.84 | EGFR (0.46) | KDM4EMAPTALDH1A1CYP3A4CYP2C19 | |
| SCHEMBL23577961 | 0.83 | KDM4E (0.49) | TSHRKDM4ETHRBPOLBMAPT | |
| SCHEMBL30036330 | 0.83 | KDM4E (0.49) | TSHRKDM4ETHRBPOLBMAPT | |
| SCHEMBL29010945 | 0.82 | SIRT6 (0.45) | KDM4ESIRT6POLBMAPTRECQL | |
| SCHEMBL30183808 | 0.81 | MAPT (0.36) | TSHRKDM4ESIRT6THRBPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115605476-B | Substituted tricyclic compounds | 鲁宾有限公司 | 2024-05-24 | — | — | CN | disclosed |
| CN-115605476-A | Substituted tricyclic compounds | 鲁宾有限公司（IN） | 2023-01-13 | — | — | CN | disclosed |