Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30514071 | 0.90 | HTT (0.45) | HTTTSHRUSP2ALDH1A1PLK1 | |
| SCHEMBL28965596 | 0.86 | KDM4E (0.52) | HTTTSHRUSP2ALDH1A1PLK1 | |
| SCHEMBL30036618 | 0.86 | KDM4E (0.52) | HTTTSHRUSP2ALDH1A1PLK1 | |
| SCHEMBL25387764 | 0.82 | MAPT (0.48) | HTTTSHRUSP2ALDH1A1PLK1 | |
| SCHEMBL8600207 | 0.77 | RORC (0.43) | HTTTSHRUSP2ALDH1A1PLK1 | |
| SCHEMBL23577961 | 0.76 | KDM4E (0.49) | HTTTSHRALDH1A1PLK1KMO | |
| SCHEMBL30036330 | 0.76 | KDM4E (0.49) | HTTTSHRALDH1A1PLK1KMO | |
| SCHEMBL25386050 | 0.74 | HPGD (0.38) | HTTTSHRALDH1A1KMT2AMEN1 | |
| SCHEMBL8127407 | 0.73 | ATAD2 (0.56) | HTTTSHRUSP2ALDH1A1PLK1 | |
| SCHEMBL17076653 | 0.73 | ATAD2 (0.52) | HTTTSHRUSP2ALDH1A1PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023165438-A1 | TRICYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | 浙江海正药业股份有限公司 | 2023-09-07 | — | — | WO | disclosed |