Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 12/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 12/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 11/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 10/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 10/20 | 0.39 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.39 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.36 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19688969 | 0.90 | CHRNB2 (0.42) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL19815874 | 0.85 | CHRNB2 (0.43) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL2939887 | 0.79 | CHRNB2 (0.35) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL18711714 | 0.79 | CHRNB2 (0.61) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL17591956 | 0.77 | CHRNB2 (0.33) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL17591955 | 0.77 | CHRNB2 (0.33) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL17591954 | 0.77 | CHRNB2 (0.33) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL28340951 | 0.75 | HSD11B1 (0.52) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL4830410 | 0.75 | HSD11B1 (0.52) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL23091843 | 0.74 | CHRNB2 (0.36) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427448-A1 | Gpr 119 modulators | Pfizer Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128414-A1 | GPR 119 MODULATORS | PFIZER INC. (US) | 2010-11-11 | — | — | WO | disclosed |