Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | PKM | P14618 | 5/20 | 0.62 |
| ▸ | RAB9A | P51151 | 9/20 | 0.56 |
| ▸ | NPC1 | O15118 | 7/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.56 |
| ▸ | RELA | Q04206 | 1/20 | 0.56 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.50 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.50 |
| ▸ | PAX8 | Q06710 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | RGS12 | O14924 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 2/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23535713 | 1.00 | MAPT (0.67) | MAPTKDM4EPOLBPKMRAB9A | |
| SCHEMBL9336728 | 0.87 | KDM4E (0.55) | MAPTKDM4EPOLBPKMRAB9A | |
| SCHEMBL13600088 | 0.84 | MAPT (0.70) | MAPTKDM4EPOLBPKMRAB9A | |
| SCHEMBL29289270 | 0.81 | RAB9A (0.60) | MAPTKDM4EPOLBPKMRAB9A | |
| SCHEMBL4311315 | 0.80 | SMN1; SMN2 (0.71) | MAPTKDM4EPOLBPKMRAB9A | |
| SCHEMBL4317855 | 0.80 | MAPT (0.65) | MAPTKDM4EPOLBPKMRAB9A | |
| SCHEMBL4317861 | 0.80 | MAPT (0.65) | MAPTKDM4EPOLBPKMRAB9A | |
| SCHEMBL27665086 | 0.80 | MAPT (1.00) | MAPTKDM4EPOLBPKMRAB9A | |
| SCHEMBL4317866 | 0.80 | MAPT (0.65) | MAPTKDM4EPOLBPKMRAB9A | |
| SCHEMBL30166417 | 0.79 | KDM4E (0.68) | MAPTKDM4EPOLBPKMRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115427035-A | ENL/AF9YEATS inhibitors | 洛克菲勒大学 | 2022-12-02 | — | — | CN | disclosed |
| EP-4076440-A1 | INHIBITORS OF ENL/AF9 YEATS | The Rockefeller University (US) | 2022-10-26 | — | — | EP | disclosed |