Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 8/20 | 0.49 |
| ▸ | NPC1 | O15118 | 6/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.49 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.47 |
| ▸ | RELA | Q04206 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.46 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.46 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30039573 | 0.87 | MAPT (0.67) | KDM4EMAPTPOLBPKMRAB9A | |
| SCHEMBL23535713 | 0.87 | MAPT (0.67) | KDM4EMAPTPOLBPKMRAB9A | |
| SCHEMBL9335427 | 0.80 | TSHR (0.62) | KDM4EMAPTPOLBRAB9ANPC1 | |
| Methyl Alcohol SCHEMBL28469619 | 0.78 | TSHR (0.67) | MAPTPOLBRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL25236791 | 0.77 | KMT2A (0.56) | MAPTPKMRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL29390740 | 0.77 | KMT2A (0.56) | MAPTPKMRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL29576494 | 0.76 | KDM4E (0.68) | KDM4EMAPTPOLBPKMRAB9A | |
| SCHEMBL30166417 | 0.76 | KDM4E (0.68) | KDM4EMAPTPOLBPKMRAB9A | |
| SCHEMBL247011 | 0.76 | KDM4E (0.68) | KDM4EMAPTPOLBPKMRAB9A | |
| SCHEMBL5562975 | 0.76 | GRM5 (0.64) | KDM4EHTTALOX15TSHRKDM6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0533695-B1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY | PFIZER (US) | 1994-10-05 | — | — | EP | disclosed |
| US-5322847-A | Inhibit platelet activating factor, block leukotriene D4 receptors | PFIZER INC. (US) | 1994-06-21 | — | — | US | disclosed |
| WO-1991017163-A1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY | PFIZER INC. (US) | 1991-11-14 | — | — | WO | disclosed |