Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.36 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.36 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 10/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 9/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24034160 | 1.00 | DYRK1A (0.41) | DYRK1AGRM5PTPN11ADRA2CTGFBR1 | |
| SCHEMBL24034191 | 0.80 | ALDH1A1 (0.41) | PTPN11TGFBR1TGFBR2ADORA2AADORA1 | |
| SCHEMBL28907472 | 0.79 | PTPN11 (0.38) | PTPN11ADRA2CTGFBR1 | |
| SCHEMBL30040707 | 0.79 | PTPN11 (0.38) | PTPN11ADRA2CTGFBR1 | |
| SCHEMBL21154583 | 0.76 | PTPN11 (0.43) | DYRK1APTPN11 | |
| SCHEMBL23186817 | 0.76 | PTPN11 (0.41) | DYRK1AGRM5PTPN11TGFBR1TGFBR2 | |
| SCHEMBL21154446 | 0.75 | PTPN11 (0.60) | PTPN11 | |
| SCHEMBL24033795 | 0.72 | PTPN11 (0.69) | PTPN11 | |
| SCHEMBL30040744 | 0.72 | PTPN11 (0.69) | PTPN11 | |
| SCHEMBL24033719 | 0.70 | PTPN11 (0.66) | PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115353509-B | Nitrogen-containing heteroaromatic derivative regulator, preparation method and application thereof | 江苏豪森药业集团有限公司 | 2024-04-12 | — | — | CN | disclosed |
| CN-115353509-A | Aza-containing aromatic derivative regulator, preparation method and application thereof | 江苏豪森药业集团有限公司 | 2022-11-18 | — | — | CN | disclosed |
| CN-111295374-B | Aza-containing aromatic derivative regulator, preparation method and application thereof | 江苏豪森药业集团有限公司 | 2022-11-04 | — | — | CN | disclosed |